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Titre : | The effectiveness and safety of Kava Kava for treating anxiety symptoms: : A systematic review and analysis of randomized clinical trials (2018) |
Auteurs : | Katelyn Smith ; Claudia Leiras |
Type de document : | Article |
Dans : | Complementary Therapies in Clinical Practice (Vol. 33, November 2018) |
Article en page(s) : | p. 107-117 |
Note générale : | https://doi.org/10.1016/j.ctcp.2018.09.003 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Anxiété ; Efficacité ; Essai clinique ; Plantes médicinales ; Revue systématique ; Signes et symptômes |
Mots-clés: | Kava |
Résumé : |
Background
To determine if Kava Kava is an effective treatment for combating symptoms of anxiety despite warnings of hepatotoxicity from the Centers for Disease Control and Prevention (CDC). Methods Databases PubMed, CINAHL, and PsycINFO were utilized to obtain clinical trials on Kava Kava and its effects on anxiety. A total of 11 articles met inclusion/exclusion criteria: 2 for Kava Kava vs. another anti-anxiety medication, 2 detailing additional adverse events, and 7 for Kava Kava vs. placebo. Mantel-Haenszel fixedeffects model was used to analyze the data, with responder rates being pooled to compute weighted risk ratios. Results Kava Kava was shown to be more effective than placebo in 3 of the 7 trials. A final risk ratio of 1.50 (95% CI: 1.12, 2.01) from responder rates was calculated in favor of the intervention from 5 clinical trials (n = 330). Adverse events were shown to be the same as placebo (P = 0.574), and laboratory values analyzing hepatotoxicity were no different when compared to baseline except in two studies. Conclusions Kava Kava appears to be a short-term treatment for anxiety, but not a replacement for prolonged anti-anxiety use. Although not witnessed in this review, liver toxicity is especially possible if taken longer than 8 weeks. |
Disponible en ligne : | Non |
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REV | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |