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Titre : | Pretreatment blood neutrophil/lymphocyte ratio is associated with metastasis and predicts survival in patients with pancreatic cancer (2018) |
Titre original: | Le ratio neutrophiles/lymphocytes préthérapeutique est associé au risque métastatique et prédit la survie chez les patients atteints de cancer du pancréas |
Auteurs : | Jing Guo ; Mengwan Wu ; Lihong Guo ; Qiang Zuo |
Type de document : | Article |
Dans : | Bulletin du cancer (Vol. 105, n° 2, Février 2018) |
Article en page(s) : | p. 146-154 |
Note générale : |
https://doi.org/10.1016/j.bulcan.2017.10.028
|
Langues: | Français |
Descripteurs : |
HE Vinci Granulocytes neutrophiles ; Leucocyte ; Métastase ; Pronostic ; Risque ; Survie ; Tumeurs du pancréas |
Résumé : |
Background
The predictive value of systemic inflammatory markers has been explored in various types of cancer. In the present study, we aimed to investigate the association between pretreatment neutrophil/lymphocyte ratio (NLR) and tumor metastasis in pancreatic cancer, and the values of NLR as a prognostic factor of overall survival. Methods Clinical and laboratory data from 256 consecutive pancreatic cancer patients were analyzed retrospectively. The NLR was recorded before treatment and analyzed along with clinicopathological characteristics and overall survival of pancreatic cancer patients. Results Multivariate analysis revealed that pretreatment NLR (HR: 2.393; 95% CI: 1.3264.320; P = 0.004) was an independent risk factor for distant metastasis. Furthermore, COX regression analysis showed that in addition to pretreatment NLR (HR: 1.871; 95% CI: 1.4132.477; P Conclusion Pretreatment NLR values were significantly associated with distant metastasis in pancreatic cancer patients. Higher NLR values were detected in metastatic disease and may be an independent prognostic factor of overall survival in pancreatic cancer patients. |
Disponible en ligne : | Non |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
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REV | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |