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Titre : | Research on expression and importance of p53, p16 and VEGF-C in cervical cancer (2015) |
Auteurs : | S. Cai, Auteur ; K. Han, Auteur |
Type de document : | Article |
Dans : | Journal de gynécologie obstétrique et biologie de la reproduction (7, Septembre 2015) |
Article en page(s) : | p. 639-645 |
Langues: | Français |
Descripteurs : |
HE Vinci Diagnostic ; Enzyme ; Génétique ; Métastase ; Pronostic ; Protéines ; Recherche ; Système immunitaire ; Tumeurs du col de l'utérus |
Résumé : |
Objective
To investigate the expression of p53, p16INK4A and VEGF-C proteins in cervical cancer and their clinical importance. Methods The expression of p53, p16INK4A and VEGF-C proteins in 125 cases of cervical sections were detected by two-step immunohistochemical EnVision method, and analyzed combined with the clinical and pathological data. Results (1) The positive expression rates of p53, p16INK4A and VEGF-C proteins were 56.8%, 95.2% and 88%, respectively. (2) The positive expression rate of p53 protein was 75% in lymph node metastasis-positive cases and 48.24% in lymph node metastasis-negative cases (P0.05). (3) The p16INK4A expression in squamous cell carcinoma is 95.65%, and it is 93.94% in adenocarcinoma, the differential expression rates bears no statistically significant, but the strong expression of squamous cell carcinoma covers 55.43% of the total number of squamous cell carcinoma, while only 15.15% rates in adenocarcinoma (P0.05). (4) Among the cases of lymph node metastasis, there were 100% of VEGF-C-positive expression and 82.35% of VEGF-C-negative expression, and the difference was significant (P0.05). |
Disponible en ligne : | Non |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
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REV | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |