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Titre : | Nutrigenetics of cholesterol metabolism: observational and dietary intervention studies in the postgenomic era (2015) |
Auteurs : | Mohammad Abdullah, Auteur ; Peter Jones, Auteur ; Peter Eck, Auteur |
Type de document : | Article |
Dans : | Nutrition reviews (73, n° 8, 2015) |
Article en page(s) : | 523-543 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Cholestérol ; Maladies cardiovasculaires ; Nutrigénomique ; Nutrition |
Résumé : | Cholesterol metabolism is a well-defined responder to dietary intakes and a classic biomarker of cardiovascular health. For this reason, circulating cholesterol levels have become key in shaping nutritional recommendations by health authorities worldwide for better management of cardiovascular disease, a leading cause of mortality and one of the most costly health problems globally. Data from observational and dietary intervention studies, however, highlight a marked between-individual variability in the response of cholesterol metabolism to similar dietary protocols, a phenomenon linked to genetic heterogeneity. This review summarizes the postgenomic evidence of polymorphisms within cholesterol-associated genes relative to fasting circulating cholesterol levels under diverse nutritional conditions. A number of cholesterol-related genediet interactions are confirmed, which may have clinical importance, supporting a deeper look into the rapidly emerging field of nutrigenetics for meaningful conclusions that may eventually lead to genetically targeted dietary recommendations in the era of personalized nutrition. |
Disponible en ligne : | Non |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
---|---|---|---|---|
REV | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |