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Titre : | Nutrition biomarkers and clinical outcomes in critically ill children : A critical appraisal of the literature (2014) |
Auteurs : | Chengsi Ong, Auteur ; Wee Meng Han, Auteur ; Judith Ju-ming wong, Auteur ; Jan Hau lee, Auteur |
Type de document : | Article |
Dans : | Clinical nutrition (vol 33, n° 2, 2014) |
Article en page(s) : | 191-197 |
Langues: | Français |
Descripteurs : |
HE Vinci Albumines ; Enfant (6-12 ans) ; Marqueurs biologiques ; Nutrition ; Pédiatrie ; Soins intensifs |
Résumé : |
Background & aims
Malnutrition can significantly affect clinical outcomes in critically ill children. In view of the limitations of anthropometry, nutrition-related serum biomarkers have been used to assess the degree of malnutrition in the pediatric intensive care unit. The aim of this review is to critically appraise the use of nutrition-related serum biomarkers in predicting clinical outcomes in critically ill children.Methods We searched major databases (MEDLINE, EMBASE, CINAHL, Cochrane Library) using MeSH terms and key words related to biomarkers, nutrition and critically ill children. All studies that explored the relationship between any nutrition-related serum biomarker and clinical outcomes in critically ill children (1 day18 years) were included. The clinical outcomes of interest were duration of intensive care unit or hospital stay, duration of mechanical ventilation and mortality. Results We found one randomized controlled trial and 15 observational studies involving 2068 children. In these 16 studies, 16 different nutritional biomarkers and two nutrition indices were examined. Albumin (n = 7), magnesium (n = 4), transferrin, prealbumin and calcium (n = 3 respectively) were the most commonly studied biomarkers. Seven biomarkers (25-hydroxyvitamin D, albumin, calcium, magnesium, total protein, transferrin, triglycerides) and two indices (modified nutritional index and Onodera's prognostic nutritional index) had positive associations with clinical outcomes. However, no biomarkers or nutrition indices consistently predicted clinical outcomes. Conclusions Current medical literature does not provide convincing data to demonstrate any association between nutrition-related serum biomarkers and clinical outcomes in critically ill children. Further research is required to identify novel and clinically robust nutrition-related biomarkers. |
Disponible en ligne : | Non |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
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REV | Périodique papier | Woluwe | Espace revues | Prêt autorisé Disponible |