Login
Communauté Vinci
Extérieur
Si votre nom d'utilisateur ne se termine pas par @vinci.be ou @student.vinci.be, utilisez le formulaire ci-dessous pour accéder à votre compte de lecteur.
Titre : | Appetite and gastrointestinal motility: Role of ghrelin-family peptides Original Research Article (2010) |
Auteurs : | S. Perboni ; A. Inui |
Type de document : | Article |
Dans : | Clinical nutrition (vol 29 n° 2, 2010) |
Article en page(s) : | pp. 227-234 |
Descripteurs : |
HE Vinci Appétit ; Ghréline ; Troubles des conduites alimentaires |
Résumé : | Summary Eating disorders, obesity and cachexia endanger the lives of millions of people worldwide. Fortunately, in last decade, there has been a rapid and substantial progress toward uncovering the molecular and neural mechanisms by which energy imbalance develops. In 1999, ghrelin was identified as the first orexigenic gut-derived peptide. It stimulates appetite and controls the gastric motility and the acid secretion through the activation of the growth hormone secretagogue-receptor. After the discovery of ghrelin, other forms of ghrelin-related proteins were isolated from the rat stomach. The unmodified des-n-octanoyl form (des-acyl ghrelin) and the recent obestatin act through distinct receptors and contrarily to acyl ghrelin, show an anorexigenic activity. The finding that these three peptide hormones derive from the same precursor exert opposing physiological actions, highlights the importance of post-translational regulatory mechanisms. Further investigations are required to highlight the complexity of ghrelin physiology in order to better understand the mechanisms regulating the energy balance and provide a successful treatment of eating disorders, obesity and cachexia. Article Outline 1. Introduction 2. Ghrelin 2.1. Acyl ghrelin 2.1.1. The mechanisms of action of acyl ghrelin 2.1.2. Acyl ghrelin is a signal for hunger 2.1.3. The pre-meal peak of ghrelin 2.1.4. Acyl ghrelin influences gut motility 2.1.5. The nutritional control of ghrelin: macronutrients 2.1.6. The nutritional control of ghrelin: gut hormones 2.1.7. Acyl ghrelin and the long-term regulation of food intake 2.1.8. The relationship between acyl ghrelin and leptin in the long-term regulation of food intake 2.2. Des-acyl ghrelin 2.2.1. Des-acyl ghrelin as an anorexigenic peptide 2.2.2. Des-acyl ghrelin as an orexigenic peptide 2.2.3. Ghrelin system and glucose and lipid metabolism 2.3. Obestatin 3. Conclusion Conflict of interest References |
Disponible en ligne : | Non |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
---|---|---|---|---|
REV | Périodique papier | Woluwe | Espace revues | Prêt autorisé Disponible |