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Titre : | Drugs on the edge of performance enhancement (2024) |
Auteurs : | Olivier Catlin ; Karol Jedrejko |
Type de document : | Article |
Dans : | actualité chimique (L') (492, février 2024) |
Article en page(s) : | p.37-42 |
Langues: | Français |
Mots-clés: | Nootropics ; anti-ischemic ; antihypoxants ; performance enhancement ; cognitive health |
Résumé : | The official laboratories responsible for detecting cases of sports doping must know very precisely the list of prohibited products (PEDs, performance-enhancing drugs, performance enhancing products) as defined and updated each year by the World Anti-Doping Agency (WADA) in order to be able to develop specific and targeted methods. These efficient modern methods are used to detect minute quantities of drugs on the list, at picogram levels and sometimes even lower. Nowadays it is very likely that any banned substance on the list will be detected. This becomes more complicated when we consider the WADA Prohibited List to include related substances in many chemical categories, making the list undefined and nearly infinite in scope. The plurality of wording and catch-all notes in many categories such as including, but not limited to, or and other substances having a similar chemical structure or similar biological effect(s), can expand the scope to include any substances related to those on the list. If an unlisted substance has a similar chemical structure to a banned substance on the list, it may be identified during targeted testing and declared to be a doping agent. This has happened twice so far: for example, for 1,3-dimethylamylamine (DMAA), detected and banned due to its similarity to tuaminoheptane, similarly for N,αdiethylphenylethylamine (N,α-DEPEA), due to similarity to methamphetamine. DMAA and N,α-DEPEA are popular illegal pre-workout supplement ingredients. However, if a substance has a similar biological effect that may provide similar performance enhancement to related substances on the WADA Prohibited List, it may escape detection by targeted testing. This therefore requires that such substances be identified first so targeted methods can be created, or detected using non-targeted methods. Several categories of substances on the WADA Prohibited List include only a few medications. Related substances that fit in these categories are likely to be abused as alternative doping agents that are not yet targeted in testing. Among these categories, nootropics and anti-ischemic and antihypoxant drugs that act as metabolic modulators are likely to improve performance and evade current targeted testing. These drugs are on the edge of performance enhancement today. |
Disponible en ligne : | Non |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
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actualité chimique (L'). 492 (février 2024) | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |