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Titre : | The Vestibular Time Constant and Clinical Response to Antimotion Sickness Medication (2023) |
Auteurs : | Daniel Lagami ; Avi Shupak ; Anna Jamison ; Dror Tal |
Type de document : | Article |
Dans : | Ear and hearing (Vol. 44, n°6, November December 2023) |
Article en page(s) : | p. 1404-1409 |
Note générale : | DOI: 10.1097/AUD.0000000000001385 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Fonction vestibulaire ; Mal des transports ; Scopolamine |
Résumé : |
Objective: The therapeutic effects of antimotion sickness medications involve suppression of several components along the vestibular system. Scopolamine-based medications have proved to be the most effective anti-seasickness agents. However, there is high variability in individual responses. The vestibular nuclei, in which the vestibular time constant is modulated, contain acetylcholine receptors which are affected by scopolamine. The hypothesis of the study was that successful seasickness prevention by scopolamine requires vestibular suppression to be reflected by the shortening of the vestibular time constant.
Design: Subjects were 30 naval crew members suffering from severe seasickness and were treated with oral scopolamine. The study participants were defined as responsive or non-responsive to the anti-seasickness medication according to the clinical outcome: successful response to scopolamine was defined as a reduction of seasickness severity from the highest score of 7 according to the Wiker scale to 4 or less. Scopolamine and placebo were assigned to each subject in a crossover, double-blind design. The horizontal semicircular canal time constant was evaluated by a computerized rotatory chair before, 1 and 2 hours after drug or placebo administration. Results: The vestibular time constant was significantly shortened from 16.01 +/- 3.43 seconds to 12.55 +/- 2.40 seconds (p Conclusions: Reduction in the vestibular time constant after scopolamine administration can be used to predict whether motion sickness alleviation will occur. This will enable the administration of appropriate pharmaceutical treatment without the need for prior exposure to sea conditions. |
Disponible en ligne : | Oui |
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