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Titre : | Segmentation and Tracing of fascicles of the vagus nerve from micro-computed tomography scans. |
Auteurs : | Félicia Turhani, Auteur ; Kirill Aristovich, Promoteur ; Nicole Thompson, Promoteur |
Type de document : | Travail de fin d'études |
Editeur : | Woluwe-Saint-Lambert : Haute École Léonard de Vinci, 2023 |
Langues: | Anglais |
Index. décimale : | TFE - Biologie médicale |
Mots-clés: | Nerf vague ; Stimulation du nerf vague ; Segmentation des faisceaux du nerf vague |
Résumé : |
The vagus nerve is the longest cranial nerve of the parasympathetic nervous system. It emanates from the brain to gastrointestinal tract and has branches that innervate many organs such as the heart, stomach and lungs. Due to its important role in the human body, the vagus nerve has become a main subject in the neuromodulation field. Vagus nerve stimulation is a promising treatment; however, current approved techniques require stimulation of the entire nerve. Therefore, this treatment is limited with unwanted off
target effects. Neuronal segmentation and tracing is a method that allows for the delineation of organspecific innervation and the development of a map of functional anatomical organisation of the nerve from microCT scans. Thus far, the organisation of three target organs, namely cardiac, pulmonary and recurrent laryngeal has been determined in pig vagus nerves. However, until now, only some left human vagus nerves have been segmented. Therefore, in this study, we used this method and traced and segmented two right human vagus nerves. Some variation was present between both nerves. Several correlation and comparison of the same organs traced have been found in pigs and in left human vagus nerves. In conclusion, the data together should be used as an information dataset for human cervical vagus nerve which could be essential for further studies. |
Accès : | Identifiez-vous avant d'accéder au document électronique |
Disponible en ligne : | Oui |
Lieu du stage : | Université College de Londres |
Département : | Biologie médicale |
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TFE - Biologie médicale Adobe Acrobat PDF |