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Titre : | Gap detection responses modelled using the Hill equation in adults with well-controlled HIV (2023) |
Auteurs : | Jay C. Buckey ; Howard J. Hoffman ; Peter Torre III |
Type de document : | Article |
Dans : | International Journal of Audiology IJA (Vol. 62, n° 5, Mai 2023) |
Article en page(s) : | p. 383-392 |
Note générale : | https://doi-org.ezproxy.vinci.be/10.1080/14992027.2022.2068083 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Seuil de détection d'écart sonore ; VIH (Virus de l'Immunodéficience humaine)Autres descripteurs Traitement auditif central (cap) |
Mots-clés: | Équation de Hill |
Résumé : |
Objective
This studys objective was determining whether gap detection deficits are present in a longstanding cohort of people living with HIV (PLWH) compared to those living without HIV (PLWOH) using a new gap detection modelling technique (i.e. fitting gap responses using the Hill equation and analysing the individual gap detection resulting curves with non-linear statistics). This approach provides a measure of both gap threshold and the steepness of the gap length/correct detection relationship. Design The relationship between the correct identification rate at each gap length was modelled using the Hill equation. Results were analysed using a nonlinear mixed-effect regression model. Study sample 45 PLWH (age range 4178) and 39 PLWOH (age range 3879) were enrolled and completed gap detection testing. Results The likelihood ratio statistic comparing the full regression model with the HIV effects to the null model, assuming one population curve for both groups, was highly significant (p Conclusions PLWH showed degraded gap detection ability compared to PLWOH, likely due to central nervous system effects of HIV infection or treatment. The Hill equation provided a new approach for modelling gap detection ability. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.tandfonline.com/doi/full/10.1080/14992027.2022.2068083 |