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Titre : | D-methionine administered as late as 36;hours post-noise exposure rescues from permanent threshold shift and dose-dependently increases serum antioxidant levels (2023) |
Auteurs : | Kathleen C. M. Campbell, Auteur ; Nicole Cosenza, Auteur ; Robert Meech, Auteur ; Michael Buhnerkempe, Auteur ; Jun Qin, Auteur ; Leonard Rybak, Auteur ; Daniel J. Fox, Auteur |
Type de document : | Article |
Dans : | International Journal of Audiology IJA (Vol. 62, no. 2, Février 2023) |
Article en page(s) : | p. 151-158 |
Note générale : | https://doi.org/10.1080/14992027.2021.2022790 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Antioxydants ; Enzyme ; Surdité due au bruitAutres descripteurs D-methionine |
Mots-clés: | otoprotection |
Résumé : |
Objective
To elucidate D-methionines (D-met) dose and time rescue parameters from steady-state or impulse noise-induced permanent threshold shift (PTS) and determine D-met rescues influence on serum and cochlear antioxidant levels. Design Five D-met doses at 0, 50, 100, or 200 mg/kg/dose administered starting at 1, 24, or 36 hours post steady-state or impulse noise exposure. Auditory brainstem responses at baseline and 21 days post-noise measured PTS. Serum (superoxide dismutase [SOD], catalase [CAT],, glutathione reductaseand glutathione peroxidase [GPx]) and cochlear (Glutathione [GSH] and glutathione disulphide [GSSG]) antioxidant levels measured physiological impact. Study Sample Chinchillas (10/study group; 68/confirmatory groups). Results D-met significantly reduced PTS for impulse noise (100 mg [2, 6, 14 and 20 kHz]; 200 mg [2, 14 and 20 kHz]) and steady-state noise (all dosing groups, time parameters and tested frequencies). PTS reduction did not significantly vary by rescue time. D-met significantly increased serum SOD (100 and 200 mg for 24 hour rescue) and GPx (50 mg/kg at 24 hour rescue) at 21 days post-noise. Cochlear GSH and GSSG levels were unaffected relative to control. Conclusion D-met rescues from steady-state and impulse noise-induced PTS even when administered up to 36 hours post-noise and dose-dependently influences serum antioxidant levels even 21 days post-noise. D-mets broad and effective dose/time window renders it a promising antioxidant rescue agent. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.tandfonline.com/doi/full/10.1080/14992027.2021.2022790 |