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Titre : | Arginine metabolism regulates the pathogenesis of inflammatory bowel disease (2023) |
Auteurs : | Jun-Yi Li ; Yan-Chao Guo ; Hai-Feng Zhou ; Tian-Tian Yue ; Fa-Xi Wang ; Fei Sun ; Wen-Zhu Wang |
Type de document : | Article |
Dans : | Nutrition reviews (Vol. 81, n° 5, May 2023) |
Article en page(s) : | p. 578-586 |
Note générale : | https://doi.org/10.1093/nutrit/nuac070 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Arginine ; Compléments alimentaires ; Inflammation ; Maladies inflammatoires intestinales ; Nutriments |
Résumé : | The pathogenesis of inflammatory bowel disease (IBD) is related to genetic susceptibility, enteric dysbiosis, and uncontrolled, chronic inflammatory responses that lead to colonic tissue damage and impaired intestinal absorption. As a consequence, patients with IBD are prone to nutrition deficits after each episode of disease resurgence. Nutritional supplementation, especially for protein components, is often implemented during the remission phase of IBD. Notably, ingested nutrients could affect the progression of IBD and the prognostic outcome of patients; therefore, they should be cautiously evaluated prior to being used for IBD intervention. Arginine (Arg) is a semi-essential amino acid required for protein synthesis and intimately associated with gut pathophysiology. To help optimize arginine-based nutritional intervention strategies, the present work summarizes that during the process of IBD, patients manifest colonic Arg deficiency and the turbulence of Arg metabolic pathways. The roles of Argnitric oxide (catalyzed by inducible nitric oxide synthase) and Argurea (catalyzed by arginases) pathways in IBD are debatable; the Argpolyamine and Argcreatine pathways are mainly protective. Overall, supplementation with Arg is a promising therapeutic strategy for IBD; however, the dosage of Arg may need to be carefully tailored for different individuals at different disease stages. Additionally, the combination of Arg supplementation with inhibitors of Arg metabolic pathways as well as other treatment options is worthy of further exploration. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/81/5/578/6679128 |