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Titre : | Leiomyosarcoma of the lower rectum managed by radiotherapy and surgery: A case report and review of literature (2023) |
Auteurs : | A. Bennassi ; H. Souhail ; A. Lo Cicero ; A. Durigova ; E. Salati |
Type de document : | Article |
Dans : | Cancer/Radiothérapie (Vol. 27, n° 3, Mai 2023) |
Article en page(s) : | p. 235-239 |
Note générale : | https://doi.org/10.1016/j.canrad.2022.10.002 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Léiomyosarcome ; Période préopératoire ; Radiothérapie adjuvante ; Rectum ; Tumeurs du rectum |
Mots-clés: | Radiothérapie néoadjuvante |
Résumé : | Rectal leiomyosarcoma is a very rare entity. Surgery is the main treatment, but the place of radiation therapy remains unclear. A 67-year-old woman was referred for a few-weeks history of bleeding and anal pain intensified during defecation. Pelvic magnetic resonance imaging (MRI) showed a rectal lesion and biopsies revealed a leiomyosarcoma of the lower rectum. She was free of metastasis on computed tomography imaging. The patient refused radical surgery. After discussion by a multidisciplinary team, the patient received pre-operative long-course radiotherapy followed by surgery. The tumor was treated with 50 Gy delivered in 25 fractions, within 5 weeks. The aim of radiotherapy was local control, allowing organ-preservation. Four weeks after radiation therapy, organ-preservation surgery could be performed. She had no adjuvant treatment. At 38-months follow-up, she had no local recurrence. However, distant recurrence (lung, liver, and bone) was detected 38 months after the resection and was managed by intra-venous doxorubicin 60 mg/m2 and dacarbazine 800 mg/m2 every 3 weeks. The patient was in a stable condition for nearly 8 months. The patient died 4 years and 3 months after the diagnosis. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S1278321823000537 |