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Titre : | An institutional review of treatment outcomes in extraosseous Ewing's sarcoma- the largest Asian experience (2023) |
Auteurs : | R.L. Chowdhary ; K.S. Chufal ; A.K. Pahuja ; I. Ahmad ; M. Sharma ; M. Jwala ; L. Kumar ; A. Sharma |
Type de document : | Article |
Dans : | Cancer/Radiothérapie (Vol. 27, n° 1, Février 2023) |
Article en page(s) : | p. 50-56 |
Note générale : | https://doi.org/10.1016/j.canrad.2022.06.008 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Analyse de regroupements ; Analyse de survie ; Asie ; Radiothérapie ; Sarcome |
Mots-clés: | Sarcome d'Ewing ; Traitement trimodal |
Résumé : |
Purpose : To analyze the treatment strategies, outcomes and factors impacting these outcomes in extraosseous ewings sarcoma (EOES).
Material and methods : A search of the hospital database yielded a total of 109 EOES patients registered in last 10 years out of which 25 patients were excluded from analysis due to incomplete medical records. Demographic and clinical characteristics were reported using descriptive statistics. Overall survival (OS) was taken from the time of diagnosis to death. Patients who were alive or lost to follow up were censored from the survival analysis. A total of 12 clinical and treatment related variables were taken into univariate analysis and those showing significance or a trend towards significance were taken up for multivariate analysis. Further a cluster analysis was done in a quest to find a subgroup which would have a better survival outcome as compared to other clusters. SPSS version 23 was used for statistical analysis. Results : Chest wall (n=26), lower extremity (n=22) and paraspinal area (n=14) were the common sites involved. Localised swelling (n=43) was the most common presenting symptom and the median time to presentation was 2 months. Overall survival of the entire cohort at 5 years was 52 percent. Stage at presentation had a significant impact (P value Conclusion : Judicious use of trimodality treatment in EOES yields optimal results and it also adds significantly onto the scarce literature on this subtype of sarcoma. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S1278321822001147 |