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Titre : | Potential inflammatory biomarkers for tinnitus in platelets and leukocytes: a critical scoping review and meta-analysis (2022) |
Auteurs : | Raheel Ahmed ; Alice Shadis ; Rumana Ahmed |
Type de document : | Article |
Dans : | International Journal of Audiology IJA (vol. 61, no. 11, novembre 2022) |
Article en page(s) : | p. 905-916 |
Note générale : | https://doi.org/10.1080/14992027.2021.2018511 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Acouphène ; Inflammation ; Leucocyte ; Marqueurs biologiques ; Plaquettes |
Résumé : |
Objective
To explore the association between platelets or leukocytes and tinnitus. Design A meta-analysis and scoping review examining the association between tinnitus and platelets and leukocytes. All 11 studies included were critically appraised using the Joanna Briggs Institute (JBI) checklist (2017a). A random effects model was used to pool the results of the studies examining mean platelet volume (MPV) and tinnitus. Study sample 1935 studies were identified in the initial search, 11 of which were included in the scoping review. 6 of the 11 studies had their MPV values pooled in the meta-analysis. Results Pooled results of 818 subjects from 6 studies indicated that MPV was significantly higher in those with tinnitus compared to a comparison group without tinnitus. The overall mean difference was 0.43 fL with a 95% confidence interval (CI) from 0.31 to 0.55 and a p value of Conclusions MPV could be a useful biomarker for tinnitus. Further studies should aim to standardise methodology with more rigorous exclusion criteria to reproduce and define this association. NLR, PLR, WBC count, RDW and PDW do not show a reliable association with tinnitus. |
Accès : | Contactez la bibliothèque d'Ixelles si le lien vers la ressource électronique ne fonctionne pas |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.tandfonline.com/doi/full/10.1080/14992027.2021.2018511 |