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Titre : | D-methionine immediate and continued rescue after noise exposure does not prevent temporary threshold shift but alters cochlear and serum antioxidant levels (2022) |
Auteurs : | Kathleen C. M. Campbell ; Nicole Cosenza ; Robert Meech ; Michael Buhnerkempe ; Jun Qin ; Leonard Rybak ; Daniel J. Fox |
Type de document : | Article |
Dans : | International Journal of Audiology IJA (vol. 61, no. 9, septembre 2022) |
Article en page(s) : | p. 769-777 |
Note générale : | https://doi.org/10.1080/14992027.2021.1959659 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Antioxydants ; Peptides ; Potentiels évoqués auditifs du tronc cérébral (ABR) ; Surdité due au bruit |
Mots-clés: | Methionine ; disulfure de glutathion ; superoxide dismutase |
Résumé : |
Objective
Determine if D-methionine (D-met) rescue prevents temporary threshold shift (TTS) from steady-state or impulse noise and determine D-mets impact on serum and cochlear antioxidant levels. Design D-met at 50, 100 or 200 mg/kg/doses were administered 0, 6 and 18 hours-post noise. ABRs at baseline and 24 hours post-noise measured TTS. Serum (SOD, CAT, GR, GPx) and cochlear (GSH, GSSG) antioxidant levels measured physiological influence. Three control groups, with impulse or steady-state or without noise, were saline-injected. Study Sample Ten Chinchillas/group. Results D-met rescue did not significantly reduce TTS or impact serum CAT, SOD, GPx or GR levels vs. noise-exposed control groups, but TTS was greater in all groups relative to no-noise controls. D-met significantly elevated CAT at 50 mg/kg vs. steady-state controls and SOD at 200 mg/kg vs. impulse noise controls. D-met significantly reduced cochlear GSH/GSSG ratios in the 100 mg/kg D-met group vs. impulse noise controls. Conclusions While D-met rescue has reduced permanent threshold shift in previous studies, it did not reduce TTS in this study. However, D-met rescue did alter selective serum and cochlear oxidative state changes 24 hours post-noise relative to controls. Results demonstrate TTS studies do not always predict PTS protection in otoprotectant experimental designs. |
Accès : | Contactez la bibliothèque d'Ixelles si le lien vers la ressource électronique ne fonctionne pas |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.tandfonline.com/doi/full/10.1080/14992027.2021.1959659 |