Login
Communauté Vinci
Extérieur
Si votre nom d'utilisateur ne se termine pas par @vinci.be ou @student.vinci.be, utilisez le formulaire ci-dessous pour accéder à votre compte de lecteur.
Titre : | Safety and Efficacy of Early Vitamin D Supplementation in Critically Ill Extremely Preterm Infants: An Ancillary Study of a Randomized Trial (2023) |
Auteurs : | Natalia Aristizabal ; Mary Pat Holder ; Leandra Durham ; Ambika P. Ashraf ; Sarah Taylor ; Ariel A. Salas |
Type de document : | Article |
Dans : | Journal of the academy of nutrition and dietetics (Vol. 123, n°1, January 2023) |
Article en page(s) : | p. 87-94 |
Note générale : | https://doi.org/10.1016/j.jand.2022.06.012 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Cholécalciférol ; Compléments alimentaires ; Disparités ; Maladie chronique ; Maladies pulmonaires ; Néonatologie ; Prématuré ; Vitamine D |
Mots-clés: | Disparités raciales ; Maladie pulmonaire chronique |
Résumé : | Background Despite substantial evidence that vitamin D deficiency is highly prevalent among infants born extremely preterm (?28 weeks? of gestation), several consensus statements do not recommend vitamin D doses >400 IU/day for these infants. Safety remains a concern. Objective The study aim was to determine safety and efficacy profiles of enteral vitamin D in Black and White infants randomized to three different vitamin D doses soon after birth. Design Ancillary study of a masked randomized clinical trial. Participants/setting Seventy-three infants born extremely preterm between 2012 and 2015 at a southern US academic neonatal unit (33? latitude) who had >90% compliance with the assigned intervention were included. Intervention Infants were randomized to receive placebo (placebo group), 200 IU/day vitamin D (200 IU group), or 800 IU/day vitamin D (800 IU group) during the first 28 days after birth. Main outcome measures Safety outcomes included serum 25-hydroxy vitamin D (25[OH]D) and calcium concentrations. Efficacy outcomes included the predictive risk of bronchopulmonary dysplasia. Statistical analysis Per-protocol analysis using unadjusted, repeated-measures mixed models. Results Mean birth weight was 815 + 199 g. Half were male and 56% were Black. Of 58 infants with 25(OH)D measurements at birth, 40 (69%) had vitamin D deficiency ( |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S2212267222003847 |