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Titre : | The safety and efficacy of probiotic supplementation for critically ill adult patients: a systematic review and meta-analysis (2023) |
Auteurs : | Abdulaziz Sulaiman Alsuwaylihi ; Fiona McCullough |
Type de document : | Article |
Dans : | Nutrition reviews (Vol. 81, n°3, March 2023) |
Article en page(s) : | p. 322-332 |
Note générale : | https://doi.org/10.1093/nutrit/nuac059 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Adulte ; Antidiarrhéiques ; Bifidobacterium ; Effets indésirables ; Lactobacillus ; Maladie grave ; Prébiotique ; Prévention et contrôle ; Probiotiques ; Soins de réanimation ; Synbiotiques ; Thérapeutique ; Unités de soins intensifs |
Résumé : |
Context: The safety and efficacy of probiotics during severe illness has been a subject of ongoing interest. The impact of probiotics can worsen nutritional status, which could potentially result in a deterioration of the patient's overall life-threatening status.
Objective: This systematic review and meta-analysis evaluated the safety and efficacy of probiotics in reducing intensive care unit (ICU)-acquired infections in adult critically ill patients. Data Sources: PubMed and Cochrane library databases for the period 2011-2020 were searched. Data Extraction: Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA) methodology was used to search for randomized controlled trials that evaluated the use of probiotics among critically ill patients. Data Analysis: No significant difference was observed between probiotics and control groups in terms of the mortality rate (risk ratio 1.13, 95% confidence interval .82 to 1.55, P?=?.46). Probiotics, however, provided a significant reduction in ICU-acquired infections (risk ratio .73, 95% confidence interval .58 to .93, P?=?.01). Conclusion: The use of probiotics seems to play a role in decreasing the incidence of ICU-acquired infections. Also, a potential reduction in terms of the incidence of diarrhea has been reported, with no examples of adverse incidents, suggesting probiotics are safe. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/81/3/322/6672573 |