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Titre : | Western and ketogenic diets in neurological disorders: can you tell the difference? (2022) |
Auteurs : | Karl John Habashy ; Fatima Ahmad ; Stanley Ibeh ; Sarah Mantash ; Fatima Kobeissy ; Hawraa Issa ; Ralph Habis ; Ali Tfaily ; Sanaa Nabha ; Hayat Harati ; Mohammad Amine Reslan ; Yara Yehya ; Chloe Barsa ; Abdullah Shaito ; Kazem Zibara ; Ahmed F El-Yazbi ; Firas H Kobeissy |
Type de document : | Article |
Dans : | Nutrition reviews (Vol. 80, n° 8, August 2022) |
Article en page(s) : | p. 1927-1941 |
Note générale : | https://doi.org/10.1093/nutrit/nuac008 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Epilepsie ; Glucides ; Maladies du système nerveux ; Obésité ; Régime cétogène ; Reproductibilité des résultats ; Vieillissement |
Résumé : | The prevalence of obesity tripled worldwide between 1975 and 2016, and it is projected that half of the US population will be overweight by 2030. The obesity pandemic is attributed, in part, to the increasing consumption of the high-fat, high-carbohydrate Western diet, which predisposes to the development of the metabolic syndrome and correlates with decreased cognitive performance. In contrast, the high-fat, low-carbohydrate ketogenic diet has potential therapeutic roles and has been used to manage intractable seizures since the early 1920s. The brain accounts for 25% of total body glucose metabolism and, as a result, is especially susceptible to changes in the types of nutrients consumed. Here, we discuss the principles of brain metabolism with a focus on the distinct effects of the Western and ketogenic diets on the progression of neurological diseases such as epilepsy, Parkinsons disease, Alzheimers disease, and traumatic brain injury, highlighting the need to further explore the potential therapeutic effects of the ketogenic diet and the importance of standardizing dietary formulations to assure the reproducibility of clinical trials. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/80/8/1927/6529526 |