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Titre : | The effect of arbutin and aerobic training on plasma leptin and adiponectin concentrations in alloxan-induced diabetic rats (2022) |
Auteurs : | Niloufar Eskandari Goodarzi ; Hoseyn Fatolahi ; Saleh Rahmati Ahmadabad ; Mehdi Pouramir ; Shiva Mohammadi ; Zohreh Khojasteh ; Mobina Aghajani ; Mohammad-Ali Azarbayjani |
Type de document : | Article |
Dans : | Nutrition clinique et métabolisme (Vol. 36, n°4, Novembre 2022) |
Article en page(s) : | p. 285-291 |
Note générale : | https://doi.org/10.1016/j.nupar.2022.09.006 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Exercice physique ; Médecine physique et de réadaptation ; Phytotherapie ; Syndrome métabolique X |
Mots-clés: | Entraînement aérobique |
Résumé : |
Background
Leptin and adiponectin are cytokines produced excessively by adipocytes, which are related to metabolic disorders. This study aimed to compare the effect of aerobic training (AT) and arbutin on leptin and adiponectin in alloxan-induced diabetic rats. Methods Eighty male Wistar rats were divided into ten groups including: (1) healthy control, (2) diabetic control, (3) healthy + arbutin, (4) diabetic + arbutin, (5) healthy + AT, (6) healthy + arbutin + AT, (7) diabetic + arbutin + AT, (8) diabetic + glibenclamide, (9) diabetic + AT, and (10) diabetic + glibenclamide + AT. Diabetes was induced in rats through the injection of 90 mg/kg saline-diluted alloxan. The AT was performed by swimming fosix weeks (five days a week). Arbutin was injected at 50 mg/kg, and glibenclamide was gavaged at 0.5 mg/kg per meal. Results Improvements of leptin, glucose, adiponectin and leptin to adiponectin ratio were different (P ≤ 0.05). Despite the significant effect of arbutin and its interaction with AT, in all cases, the effect of glibenclamide consumption was greater compared to arbutin (P = 0.001). Interaction of AT with glibenclamide also increased this effect (P = 0.001). Conclusion Rehabilitation exercise and arbutin may offer a solution for the treatment of diabetes. However, the effect of this treatment is less than compared to glibenclamide, which may be further improved through changing the dose of arbutin or AT. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S098505622200084X |