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Titre : | High-dose salvage re-irradiation in recurrent/progressive adult diffuse gliomas: development of a novel prognostic scoring system (2022) |
Auteurs : | M. Maitre ; T. Gupta ; P. Maitre ; Abihishek Chatterjee ; A. Dasgupta ; A. Moiyadi ; P. Shetty ; S. Epari ; A. Sahay ; V. Patil ; R. Krishnatry ; G.J. Sastri ; R. Jalali |
Type de document : | Article |
Dans : | Cancer/Radiothérapie (vol. 26, no. 8, Novembre 2022) |
Article en page(s) : | p. 994-1001 |
Note générale : | https://doi-org.ezproxy.vinci.be/10.1016/j.canrad.2022.01.004 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Pronostic ; Récidive ; Réirradiation ; Survie |
Mots-clés: | Gliome diffus ; gliome protubérantiel infiltrant |
Résumé : | Purpose Over the past two decades, high-dose salvage re-irradiation (re-RT) has been used increasingly in the multimodality management of adults with recurrent/progressive diffuse glioma. Several factors that determine outcomes following re-RT have been incorporated into prognostic models to guide patient selection. We aimed to develop a novel four-tiered prognostic model incorporating relevant molecular markers from our single-institutional cohort of patients treated with high-dose salvage re-RT for recurrent/progressive diffuse glioma. Material and methods Various patient, disease, and treatment-related factors impacting upon survival following salvage re-RT were identified through univariate analysis. Each of these prognostic factors was further subdivided and assigned scores of 0 (low-risk), 1 (intermediate-risk), or 2 (high-risk). Scores from individual prognostic factors were added to derive the cumulative score (ranging from 0 to 16), with increasing scores indicating worsening prognosis. Results A total of 111 adults with recurrent/progressive diffuse glioma treated with salvage high-dose re-RT were included. We could assign patients into four prognostic subgroups (A=15 patients, score 0?3); (B=50 patients, score 4?7); (C=33 patients, score 8?10); and (D=13 patients, score 11?16) with completely non-overlapping survival curves suggesting the good discriminatory ability. Post-re-RT survival was significantly higher in Group A compared to groups B, C, and D, respectively (stratified log-rank p-value |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S1278321822000427 |