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Titre : | Survival impact of postoperative radiotherapy in patients with olfactory neuroblastoma: 513 cases from the SEER database (2022) |
Auteurs : | G.-S. Duo ; J.-L. Feng ; Zhiyan Zhang ; L.-J. Wang |
Type de document : | Article |
Dans : | Cancer/Radiothérapie (vol. 26, no. 5, Septembre 2022) |
Article en page(s) : | p. 663-669 |
Note générale : | https://doi-org.ezproxy.vinci.be/10.1016/j.canrad.2021.12.006 |
Langues: | Français |
Descripteurs : |
HE Vinci Chimiothérapie ; Pronostic ; Radiothérapie ; Soins postopératoires |
Mots-clés: | Esthésioneuroblastome olfactif ; Neuroblastome olfactif ; Radiothérapie postopératoire |
Résumé : |
Pupose
To evaluate the impact of postoperative radiotherapy (PORT) on survival in olfactory neuroblastoma (ONB) patients with different tumor staging. Material and methods Patients with ONB were selected in the Surveillance, Epidemiology and End Results (SEER) database from 20042016. Survival analyses were performed using KaplanMeier (K-M) method, Cox regression analysis, and competing risk model. Results A total of 513 patients were included in the study. Univariate and multivariate analysis results demonstrated that PORT was not an independent prognostic factor for overall survival (OS) of modified Kadish stage A and B patients (P = 0.699 and P = 0.248, respectively). Kadish stage C and D patients who underwent PORT had significantly better OS than those who did not undergo PORT (P = 0.03 and P 0.05). Conclusion Our results indicate that PORT improved survival outcomes of modified Kadish stage C and D ONB patients. However, PORT may not affect survival for modified Kadish stage A and B individuals. Chemotherapy was not recommended for ONB; therefore, further studies are warranted to determine its therapeutic significance. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S1278321822000361 |