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Titre : | Brachytherapy: An emblematic example of extreme hypofractionated regimen (2022) |
Auteurs : | Jean-Michel Hannoun-Lévi ; N. Pujol ; M. Gautier ; M.-E. Chand |
Type de document : | Article |
Dans : | Cancer/Radiothérapie (vol. 26, no. 4, Juin 2022) |
Article en page(s) : | p. 611-615 |
Note générale : | https://doi-org.ezproxy.vinci.be/10.1016/j.canrad.2021.09.008 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Curiethérapie ; Radiothérapie ; Tumeurs de la prostate ; Tumeurs du sein |
Mots-clés: | Hypofractionnement extrème |
Résumé : | In order to provide more convenient irradiation regimens for patient comfort, radiation facility organization and health expenses, new hypofractionated protocols have been evaluated. Moderately (dose/fraction: 2.3 to 3Gy), then ultra (dose/fraction: 5.2 to 6.1Gy) hypofractionated irradiations were first validated. The current question is: is it possible to go forward using extreme hypofractionated regimens (EHR) based on 1 to 3 fractions. Different irradiation techniques are under investigation. However, brachytherapy remains the smartest way to deliver a high dose in a small volume. We report prospective and retrospective study results which evaluated EHR for breast and prostate brachytherapy. While oncological outcome and toxicity profile appear extremely encouraging for low-risk breast cancer after a 1 to 4 fractions (6.25 to 20Gy/fraction), the use of a single fraction of 19 to 23Gy appears debatable for prostate cancer. Brachytherapy represents an emblematic example of EHR but longer follow-up and more mature results are awaited in order to specify the right indications and refine the EQD2 calculation method including new biological and technical factors. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S1278321821002560 |