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Titre : | Unusual severe radiation-induced toxicity in a patient with discoid lupus erythematosus: A case report and critical review of the literature (2022) |
Auteurs : | S. Allali ; F. Chasset ; Y. Kirova ; C. Saint-Martin ; P. Moguelet ; A. Fourquet ; A. Beddok |
Type de document : | Article |
Dans : | Cancer/Radiothérapie (vol. 26, no. 4, Juin 2022) |
Article en page(s) : | p. 594-598 |
Note générale : | https://doi-org.ezproxy.vinci.be/10.1016/j.canrad.2021.07.039 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Lupus érythémateux disséminé ; Radiothérapie ; Tolérance |
Résumé : | Data on the incidence and severity of radiation-induced toxicity in patients with systemic and/or cutaneous lupus erythematosus (SLE/CLE) are very limited. After reporting the case of a patient who experienced major toxicity and CLE flare in the irradiated area following breast irradiation, we conducted a comprehensive literature review of available data in this setting. The few retrospectives studies which have evaluated both the risk of toxicity in SLE/CLE patients and/or the potential induction or reactivation of SLE/CLE with radiotherapy have not shown differences between SLE/CLE patients and controls. Several other factors such as concurrent chemotherapy, a particular genetic background, or lupus treatments (essentially hydroxychloroquine) can explain severe radiation-induced toxicity. Therefore, patients with SLE/CLE should be irradiated like patients without SLE/CLE, with close monitoring during radiotherapy if other risk factors exist. Further studies examining a larger number of patients would probably allow a better understanding of the radiosensitivity of these patients. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S1278321821002651 |