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Titre : | The Resting State Central Auditory Network: a Potential Marker of HIV-Related Central Nervous System Alterations (2022) |
Auteurs : | Yi Zhan ; Qiurong Yu ; Dan-Chao Cai ; James C. Ford ; Xiudong Shi ; Abigail M Fellows ; Odile H. Clavier ; Sigfrid D. Soli ; Mingxia Fan ; Hongzhou Lu ; Zhiyong Zhang ; Jay C. Buckey ; Yuxin Shi, Auteur |
Type de document : | Article |
Dans : | Ear and hearing (Vol. 43, n°4, Juillet-Aout 2022) |
Article en page(s) : | p. 1222-1227 |
Note générale : | DOI: 10.1097/AUD.0000000000001186 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Imagerie par résonance magnétique ; Syndrome d'immunodéficience acquise (SIDA) ; Système nerveux central ; Troubles de l'audition centrale |
Résumé : |
Objective: HIV positive (HIV+) individuals with otherwise normal hearing ability show central auditory processing deficits as evidenced by worse performance in speech-in-noise perception compared with HIV negative (HIV-) controls. HIV infection and treatment are also associated with lower neurocognitive screening test scores, suggesting underlying central nervous system damage. To determine how central auditory processing deficits in HIV+ individuals relate to brain alterations in the cortex involved with auditory processing, we compared auditory network (AN) functional connectivity between HIV+ adults with or without speech-in-noise perception difficulties and age-matched HIV- controls using resting-state fMRI.
Design: Based on the speech recognition threshold of the hearing-in-noise test, twenty-seven HIV+ individuals were divided into a group with speech-in-noise perception abnormalities (HIV+SPabnl, 38.2 +/- 6.8 years; 11 males and 2 females) and one without (HIV+SPnl 34.4 +/- 8.8 years; 14 males). An HIV- group with normal speech-in-noise perception (HIV-, 31.3 +/- 5.2 years; 9 males and 3 females) was also enrolled. All of these younger and middle-aged adults had normal peripheral hearing determined by audiometry. Participants were studied using resting-state fMRI. Independent component analysis was applied to identify the AN. Group differences in the AN were identified using statistical parametric mapping. Results: Both HIV+ groups had increased functional connectivity (FC) in parts of the AN including the superior temporal gyrus, middle temporal gyrus, supramarginal gyrus, and Rolandic operculum compared to the HIV- group. Compared with the HIV+SPnl group, the HIV+SPabnl group showed greater FC in parts of the AN including the middle frontal and inferior frontal gyri. Conclusions: The classical auditory areas in the temporal lobe are affected by HIV regardless of speech perception ability. Increased temporal FC in HIV+ individuals might reflect functional compensation to achieve normal primary auditory perception. Furthermore, increased frontal FC in the HIV+SPabnl group compared with the HIV+SPnl group suggest that speech-in-noise perception difficulties in HIV-infected adults also affect areas involved in higher-level cognition, providing imaging evidence consistent with the hypothesis that HIV-related neurocognitive deficits can include central auditory processing deficits. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=yrovftz&AN=00003446-202207000-00012 |