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Titre : | Are systematic reviews addressing nutrition for cancer prevention trustworthy? A systematic survey of quality and risk of bias (2022) |
Auteurs : | Joanna F Zajac ; Dawid Storman ; Mateusz J Swierz ; Magdalena Koperny ; Paulina Weglarz ; Wojciech Staskiewicz ; Magdalena Gorecka ; Anna Skuza ; Adam Wach ; Klaudia Kaluzinska ; Justyna Bochenek-Cibor ; Bradley C Johnston ; Malgorzata M Bala |
Type de document : | Article |
Dans : | Nutrition reviews (Vol. 80, n° 6, June 2022) |
Article en page(s) : | p. 1558-1567 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Biais (épidémiologie) ; Épidémiologie ; Etiologie ; Prestations des soins de santé ; Prévention et contrôle ; Revues systématiques comme sujet ; Tumeurs |
Résumé : | Context: The last 30?years have yielded a vast number of systematic reviews and/or meta-analyses addressing the link between nutrition and cancer risk.; Objective: The aim of this survey was to assess overall quality and potential for risk of bias in systematic reviews and meta-analyses (SRMAs) that examined the role of nutrition in cancer prevention.; Data Sources: MEDLINE, Embase, and the Cochrane Library databases were searched (last search performed November 2018).; Study Selection: Studies identified as SRMAs that investigated a nutritional or dietary intervention or exposure for cancer prevention in the general population or in people at risk of cancer and in which primary studies had a comparison group were eligible for inclusion. Screening, data extraction, and quality assessment were conducted independently by 2 reviewers.; Data Extraction: Altogether, 101 studies were randomly selected for analysis. The methodological quality and risk of bias were evaluated using the AMSTAR-2 and ROBIS tools, respectively.; Results: Most SRMAs included observational studies. Less than 10% of SRMAs reported a study protocol, and only 51% of SRMAs assessed the risk of bias in primary studies. Most studies conducted subgroup analyses, but only a few reported tests of interaction or specified subgroups of interest a priori. Overall, according to AMSTAR-2, only 1% of SRMAs were of high quality, while 97% were of critically low quality. Only 3% had a low risk of bias, according to ROBIS.; Conclusions: This systematic survey revealed substantial limitations with respect to quality and risk of bias of SRMAs. SRMAs examining nutrition and cancer prevention cannot be considered trustworthy, and results should be interpreted with caution. Peer reviewers as well as users of SRMAs should be advised to use the AMSTAR-2 and/or ROBIS instruments to help to determine the overall quality and risk of bias of SRMAs. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/80/6/1558/6469058 |