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Titre : | Robot-assisted gait training with auditory and visual cues in Parkinson's disease: A randomized controlled trial (2022) |
Auteurs : | Heejae Kim ; Eunkyung Kim ; Seo Jung Yun ; Min-Gu Kang ; Hyun Iee Shin ; Byung-Mo Oh ; Gil Seo Han |
Type de document : | Article |
Dans : | Annals of Physical and Rehabilitation Medicine (Vol. 65, n° 3, May 2022) |
Article en page(s) : | 9 p. |
Note générale : | https://doi.org/10.1016/j.rehab.2021.101620 |
Langues: | Français |
Descripteurs : |
HE Vinci Entrainement d'endurance ; Essais cliniques comme sujet ; Imagerie par résonance magnétique ; Maladie de Parkinson ; Marche à pied |
Mots-clés: | Interférence cognitive à double tâche |
Résumé : | Background Robot-assisted gait training (RAGT) may have beneficial effects on Parkinson's disease (PD); however, the evidence to date is inconsistent. Objectives This study compared the effects of RAGT and treadmill training (TT) on gait speed, dual-task gait performance, and changes in resting-state brain functional connectivity in individuals with PD. Methods In this prospective, single-center, randomized controlled trial with a parallel two-group design, 44 participants were randomly allocated to undergo 12 sessions (3 times per week for 4 weeks) of RAGT or TT. The primary outcome was gait speed on the 10-m walk test (10mWT) under comfortable walking conditions. Secondary outcomes included dual-task interference on gait speed, balance, disability scores, fear of falling, freezing of gait, and brain functional connectivity changes. All clinical outcomes were measured before (T0), immediately after (T1), and 1 month after treatment (T2). Results The mean (SD) age of the participants was 68.1 (8.1) years, and mean disease duration 108.0 (61.5) months. The groups did not significantly differ on the 10mWT (T0-T1, p = 0.726, Cohen's d = 0.133; T0-T2, p = 0.778, Cohen's d = 0.121). We observed a significant time-by-group interaction (F = 3.236, p = 0.045) for cognitive dual-task interference, controlling for confounders. After treatment, coupling was decreased to a greater extent with RAGT than TT between the visual and dorsal attention networks (p = 0.015), between bilateral fronto-parietal networks (p = 0.043), and between auditory and medial temporal networks (p = 0.018). Improvement in cognitive dual-task interference was positively correlated with enhanced visual and medial temporal network coupling overall (r = 0.386, p = 0.029) and with TT (r = 0.545, p = 0.024) but not RAGT (r = 0.151, p = 0.590). Conclusions RAGT was not superior to intensity-matched TT on improving gait functions in individuals with PD but may be beneficial in improving gait ability under cognitive dual-task conditions. The therapeutic mechanism and key functional connectivity changes associated with improvement may differ between treatment strategies. ClinicalTrials.gov #NCT03490578 |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S1877065721001378 |