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Titre : | The intestinal luminal sources of a-synuclein : a gastroenterologist perspective (2022) |
Auteurs : | A. Lerner |
Type de document : | Article |
Dans : | Nutrition reviews (Vol. 80, n°2, February 2022) |
Article en page(s) : | p. 282-293 |
Note générale : | https://doi.org/10.1093/nutrit/nuab024 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Gastroentérologie ; Intestins ; Maladie de Parkinson ; Nutriments ; Système nerveux |
Résumé : | Parkinsons disease is characterized by nonmotor/motor dysfunction, midbrain dopaminergic neuronal death, and α-synuclein (aSN) deposits. The current hypothesis is that aSN accumulates in the enteric nervous system to reach the brain. However, invertebrate, vertebrate, and nutritional sources of aSN reach the luminal compartment. Submitted to local amyloidogenic forces, the oligomerized proteins cargo can be sensed and sampled by a specialized mucosal cell to be transmitted to the adjacent enteric nervous system, starting their upward journey to the brain. The present narrative review extends the current mucosal origin of Parkinsons disease, presenting the possibility that the disease starts in the intestinal lumen. If substantiated, eliminating the nutritional sources of aSN (eg, applying a vegetarian diet) might revolutionize the currently used dopaminergic pharmacologic therapy. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/80/2/282/6263431 |