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Titre : | Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease (2021) |
Auteurs : | Ludmila F. M. De França Cardozo ; Livia A. Alvarenga ; Marcia Ribeiro ; Lu Dai ; Paul G. Shiels ; Peter Stenvinkel ; Bengt Lindholm ; D. Mafra |
Type de document : | Article |
Dans : | Nutrition reviews (Vol. 79, n°11, November 2021) |
Article en page(s) : | p. 1204-1224 |
Note générale : | https://doi.org/10.1093/nutrit/nuaa129 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Défaillance rénale chronique ; Inflammation ; Maladie chronique ; Microbiome gastro-intestinal ; Régime alimentaire ; Vieillissement |
Résumé : | Sulforaphane (SFN) is a sulfur-containing isothiocyanate found in cruciferous vegetables (Brassicaceae) and a well-known activator of nuclear factor-erythroid 2-related factor 2 (Nrf2), considered a master regulator of cellular antioxidant responses. Patients with chronic diseases, such as diabetes, cardiovascular disease, cancer, and chronic kidney disease (CKD) present with high levels of oxidative stress and a massive inflammatory burden associated with diminished Nrf2 and elevated nuclear transcription factor-κB-κB expression. Because it is a common constituent of dietary vegetables, the salutogenic properties of sulforaphane, especially its antioxidative and anti-inflammatory properties, have been explored as a nutritional intervention in a range of diseases of ageing, though data on CKD remain scarce. In this brief review, the effects of SFN as a senotherapeutic agent are described and a rationale is provided for studies that aim to explore the potential benefits of SFN-rich foods in patients with CKD. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/79/11/1204/6041747 |