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Titre : | Gut microbiotaassociated trimethylamine N-oxide and increased cardiometabolic risk in adults: a systematic review and dose-response meta-analysis (2021) |
Auteurs : | Mahdieh Abbasalizad Farhangi ; Mahdi Vajdi |
Type de document : | Article |
Dans : | Nutrition reviews (Vol. 79, n° 9, September 2021) |
Article en page(s) : | p. 10221042 |
Note générale : | doi:10.1093/nutrit/nuaa111 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Adulte ; Hypertension artérielle ; Maladies cardiovasculaires ; Microbiome gastro-intestinal |
Mots-clés: | facteurs de risque cardiométaboliques ; lipides sériques ; Oxyde de triméthylamine |
Résumé : |
Context:
Several studies suggest a relationship between trimethylamine N-oxide (TMAO) concentrations and increased cardiometabolic risk, but findings are controversial. Objective: The aim of this systematic review and meta-analysis was to summarize evidence of the relationship between circulating TMAO levels and risk of hypertension and increased serum lipids in a dose-response and 2-class meta-analysis of discrete and continuous variables. Data Sources: PubMed, Scopus, Cochrane, and ProQuest databases were searched. Study Selection: Observational studies that reported disease status of participants (≥ 18 years), type of sample in which TMAO was measured (serum or plasma), and results based on at least 2 categories of TMAO concentrations, including relative risks, hazard ratios, or odds ratios with 95%CIs for cardiometabolic risk factors in association with circulating TMAO levels were selected. Papers were reviewed independently by both authors. The Newcastle-Ottawa Scale was used to assess the quality of included studies. Data Extraction: The following data were extracted: first authors name, publication year, study design, study location, demographic information of participants, and concentrations of circulating TMAO. Results: Eighteen studies were included in the meta-analysis. There was a dose-response relationship between circulating TMAO and increased odds of hypertension in cohort studies (P for nonlinearity = 0.049), in plasma-derived TMAO samples (P for nonlinearity = 0.043), in patients with cardiovascular disease (P for nonlinearity = 0.048), and in apparently healthy individuals from community-based studies (P for nonlinearity = 0.005). Moreover, the highest category of TMAO concentrations was associated with a 2.36 mmHg increase in systolic blood pressure when compared with the lowest category. The dose-response meta-analysis of continuous variables revealed that an increase in TMAO is associated with reduced high-density lipoprotein cholesterol in apparently healthy individuals and reduced high-density lipoprotein cholesterol and increased total cholesterol in patients with cardiovascular disease. Conclusions: Circulating TMAO is positively associated with an increased risk of hypertension and other cardiometabolic disorders in adults. Systematic Review Registration: PROSPERO identification number CRD42019138296. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/79/9/1022/6019953 |