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Titre : | The effects of nano-curcumin supplementation on Th1/Th17 balance in migraine patients: A randomized controlled clinical trial (2020) |
Auteurs : | Mona Djalali ; Mina Abdolahi ; Reza Hosseini ; et al. |
Type de document : | Article |
Dans : | Complementary Therapies in Clinical Practice (Vol. 41, November 2020) |
Article en page(s) : | 101256 |
Note générale : | https://doi.org/10.1016/j.ctcp.2020.101256 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Curcumine ; Essai clinique ; Inflammation ; Interleukine-17 ; Migraines ; Thérapies complémentaires |
Résumé : |
Background
The present study was aimed to evaluate the nano-curcumin supplementation on Th1/Th17 balance by assessment of gene expression and serum level of interferon gamma (IFN-γ) and interleukin-17 (IL-17) in migraine patients. Methods Forty participants with episodic migraine were randomly allocated to receive 80 mg nano-curcumin (n = 20) or placebo (n = 20) in a randomized double-blind clinical trial for two months. The expression of IFN-γ and IL-17 from peripheral blood mononuclear cells and IFN-γ and IL-17 serum levels were measured, using a real-time PCR and ELISA methods, respectively. Results Compared to placebo group, two month nano-curcumin supplementation led to a significant reduction in serum levels and expression of IL-17 mRNA (P = 0.006 & 0.04, respectively), while there was no statistical difference regarding serum levels and expression of IFN-γ mRNA. Conclusion Nano-curcumin supplementation in migraine patients led to a significant reduction in gene expression and plasma levels of IL-17 compared to control group. |
Disponible en ligne : | Non |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
---|---|---|---|---|
Complementary Therapies in Clinical Practice. Vol. 41 (November 2020) | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |