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Titre : | Vitamin D suppresses proangiogenic factors in patients with ulcerative colitis: A randomized double blind placebo controlled clinical trial (2020) |
Auteurs : | Mohammad Reza Emami ; Amrollah Sharifi ; Mehdi Yaseri ; et al. |
Type de document : | Article |
Dans : | Complementary Therapies in Clinical Practice (Vol. 39, May 2020) |
Article en page(s) : | 5p. |
Note générale : | https://doi.org/10.1016/j.ctcp.2020.101086 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Essai clinique ; Facteur de croissance endothéliale vasculaire de type A ; Nicotinamide phosphoribosyltransferase ; Rectocolite hémorragique ; Vitamine D |
Résumé : |
Background
Angiogenesis and inflammation are involved in the pathogenesis of ulcerative colitis (UC). This study aimed to assess the effect of vitamin D on serum levels of proangiogenic factors, visfatin and vascular endothelial growth factor (VEGF), in patients with UC. Materials and methods Ninety patients were randomized to receive either a single intramuscular injection of 300,000 IU vitamin D or normal saline. Visfatin, VEGF, and 25-hydroxyvitamin D [25(OH)D] concentrations were assessed before and 90 days after the intervention. Results There were no significant differences in visfatin and VEGF levels between the two groups following supplementation. In patients with vitamin D insufficiency, visfatin increase was significantly lower in the intervention versus placebo group. There was an inverse correlation between serum 25(OH)D and visfatin in the subgroup with vitamin D insufficiency. Conclusion Vitamin D might be beneficial in decreasing proangiogenic factors such as visfatin in UC patients with low 25(OH)D levels. |
Disponible en ligne : | Non |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
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Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |