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Titre : | Long-chain omega-3 polyunsaturated fatty acids and cognitive decline in non-demented adults: a systematic review and meta-analysis (2020) |
Auteurs : | Anu Alex ; Kylie A. Abbott ; Mark McEvoy ; Peter W. Schofield ; Manohar L. Garg |
Type de document : | Article |
Dans : | Nutrition reviews (Vol. 78, n° 7, July 2020) |
Article en page(s) : | p. 563578 |
Note générale : | doi:10.1093/nutrit/nuz073 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Acide docosahexaénoïque ; Acides gras omega-3 ; Adulte (19-44 ans) ; Cognition ; Dysfonctionnement cognitif |
Résumé : |
Context:
Long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFAs) are widely considered as nootropic agents that may be beneficial in reversing cognitive impairment. Objective: The present systematic review of randomized controlled trials was conducted to determine the changes in cognitive function after intervention with LCn-3PUFA supplementation in non-demented adults, including those with mild cognitive impairment. Data Sources: Five databases (MEDLINE, CINAHL, Scopus, EMBASE, and the Cochrane Library) were searched systematically along with reference lists of selected articles. Study Selection: Studies were eligible for inclusion if they measured the effect of LCn-3PUFA supplementation on cognition in non-demented adults. Data Extraction: A total of 787 records were screened, of which 25 studies were eligible for inclusion. Treatment effects were summarized as global cognitive function for primary outcome and measured using the Mini-Mental State Examination and individual cognitive domains for secondary outcome. The pooled effect sizes were estimated using Hedges g and random-effects modeling. Data Analysis: Results from randomized controlled trials indicate that LCn-3PUFAs have no effect on global cognitive function (Hedges g = 0.02; 95% confidence interval, −0.12 to 0.154), and among the specific cognitive domains, only memory function showed a mild benefit (Hedges g = 0.31; P = 0.003; z = 2.945). Conclusion: The existing literature suggests that LCn-3PUFA supplementation could provide a mild benefit in improving memory function in non-demented older adults. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/78/7/563/5678779 |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
---|---|---|---|---|
Nutrition reviews. Vol. 78, n° 7 (July 2020) | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |