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Titre : | D-methionine pre-loading reduces both noise-induced permanent threshold shift and outer hair cell loss in the chinchilla (2013) |
Auteurs : | Alexander D Claussen, A ; Daniel J. Fox ; Xin Yu |
Type de document : | Article |
Dans : | International Journal of Audiology IJA (Vol.52, n°12, December 2013) |
Langues: | Anglais |
Résumé : | Objective: This study tested multiple dosing epochs of pre-loaded D-methionine (D-met) for otoprotection from noise-induced hearing loss (NIHL). Design: Auditory brainstem response (ABR) thresholds were measured at baseline, 1 day, and 21 days following a 6-hour 105 dB sound pressure level (SPL) octave band noise (OBN) exposure. Outer hair cell (OHC) counts were measured after day 21 sacrifice. Study sample: Three groups of five Chinchillas laniger each were given a 2-day regimen comprising five doses of D-met (200 mg/kg/dose) intraperitoneally (IP) starting 2, 2.5, or 3 days prior to noise exposure. A control group (n = 5) received five doses of equivalent volume saline IP starting 2.5 days prior to noise exposure. Results: ABR threshold shifts from baseline to day-21 post-noise exposure were reduced in all D-met groups versus controls, reaching significance (p |
Accès : | Contactez la bibliothèque d'Ixelles si le lien vers la ressource électronique ne fonctionne plus |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.tandfonline.com/doi/full/10.3109/14992027.2013.840933 |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
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International journal of audiology IJA. Vol.52, n°12 (December 2013) | Périodique papier | Ixelles | Rez | Consultation sur place uniquement Exclu du prêt |