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Titre : | Potential relationship between dietary long-chain saturated fatty acids and hypothalamic dysfunction in obesity (2020) |
Auteurs : | Domenico Sergi ; Lynda M. Williams |
Type de document : | Article |
Dans : | Nutrition reviews (Vol. 78, n° 4, April 2020) |
Article en page(s) : | p. 261-277 |
Note générale : | doi:10.1093/nutrit/nuz056 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Acides gras ; Hypothalamus ; Inflammation ; Produits terminaux de glycation avancée |
Mots-clés: | lipotoxicité ; acides gras saturés à longue chaîne |
Résumé : | Diet-induced hypothalamic inflammation, which leads to hypothalamic dysfunction and a loss of regulation of energy balance, is emerging as a potential driver of obesity. Excessive intake of long-chain saturated fatty acids is held to be the causative dietary component in hypothalamic inflammation. This review summarizes current evidence on the role of long-chain saturated fatty acids in promoting hypothalamic inflammation and the related induction of central insulin and leptin insensitivity. Particularly, the present review focuses on the molecular mechanisms linking long-chain saturated fatty acids and hypothalamic inflammation, emphasizing the metabolic fate of fatty acids and the resulting lipotoxicity, which is a key driver of hypothalamic dysfunction. In conclusion, long-chain saturated fatty acids are key nutrients that promote hypothalamic inflammation and dysfunction by fostering the build-up of lipotoxic lipid species, such as ceramide. Furthermore, when long-chain saturated fatty acids are consumed in combination with high levels of refined carbohydrates, the proinflammatory effects are exacerbated via a mechanism that relies on the formation of advanced glycation end products. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/78/4/261/5571424 |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
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Nutrition reviews. Vol. 78, n° 4 (April 2020) | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |