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Titre : | Is strength training feasible for young people with Prader-Willi syndrome? A phase I randomised controlled trial (2020) |
Auteurs : | Nora Shields ; Kim Bennell ; Jessica Radcliffe ; Nicholas F. Taylor |
Type de document : | Article |
Dans : | Physiotherapy (Vol. 106, n° 1, Mars 2020) |
Article en page(s) : | p. 136-144 |
Note générale : | https://doi.org/10.1016/j.physio.2019.01.016 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Entraînement en résistance ; Etude clinique ; Force musculaire ; Mise en condition physique de l'homme ; Personnes handicapées ; Syndrome de Prader-Willi |
Résumé : |
Objective
To investigate the feasibility of progressive resistance training for people with Prader-Willi syndrome (PWS), who have muscle weakness and very low muscle mass. Design Randomised controlled trial with concealed allocation, assessor blinding and intention-to-treat analysis. Setting Community gymnasium. Participants Sixteen participants with PWS (eight female; mean age 25 years) were randomly assigned with 1:1 allocation to an experimental (n = 8) or control group (n = 8). Intervention Progressive resistance training was performed twice a week for 10 weeks. The training was supervised one-to-one by a physiotherapist and comprised seven exercises. The control group continued their usual activities and were offered the training after follow-up assessment. Main outcome measures Three domains of feasibility were evaluated: implementation (attendance and adherence), practicality (safety) and limited efficacy testing. Muscle strength (one repetition maximum for chest and leg press), physical function (box stacking test, timed stairs climb), muscle composition (US) and body composition (whole-body DXA scan) were measured before and after the intervention. Results Participants attended 92% of scheduled sessions and adhered by progressing their training resistance by 82% (range 60140%). There was one unexpected serious adverse event unrelated to the intervention and several non-serious expected adverse events related to the intervention. Estimates of standardised mean differences indicated moderate to large effects in favour of the experimental group for arm (0.92, 95%CI −0.11 to 1.95) and leg strength (0.78, 95%CI −0.27 to 1.83). The effect was uncertain for secondary outcomes. Conclusions There is preliminary evidence showing progressive resistance training is feasible for people with Prader-Willi syndrome and may increase muscle strength. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S0031940619300380 |