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Titre : | The conundrum of dietary antioxidants in cancer chemotherapy (2020) |
Auteurs : | Roghayeh Ilghami ; Abolfazl Barzegari ; Mohammad Reza Mashayekhi ; Didier Letourneur ; Michel Crepin ; Graciela Pavon-Djavid |
Type de document : | Article |
Dans : | Nutrition reviews (Vol. 78, n° 1, January 2020) |
Article en page(s) : | p.6576 |
Note générale : | https://doi.org/10.1093/nutrit/nuz027 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Antioxydants ; Caroténoïdes ; Chimiothérapie ; Effets secondaires indésirables des médicaments ; Stress oxydatif ; Tumeurs |
Résumé : | Although chemotherapy succeeds in reducing tumor burden, the efficacy is limited due to acquired drug resistance and often irreparable side effects. Studies show that antioxidants may influence the response to chemotherapy and its side effects, although their use remains controversial. The evidence shows that some chemo-drugs induce oxidative stress and lead to normal tissue apoptosis and the entry of cancer cells to a dormant G0 state. Through the suppression of oxidative stress, antioxidants could protect normal cells and bring the tumor out of dormancy so as to expose it to chemotherapies. This review is focused on the redox biology of cancer/normal cells and association of reactive oxygen species with drug resistance, cancer dormancy, and side effects. To this end, evidence from cellular, animal, and clinical studies is provided to better understand the conundrum of dietary antioxidants in cancer chemotherapy. |
Disponible en ligne : | Oui/Non |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/78/1/65/5549273 |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
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Nutrition reviews. Vol. 78, n° 1 (January 2020) | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |