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Titre : | Cerebellar White Matter Damage Is Associated With Postural Sway Deficits in People With Multiple Sclerosis (2020) |
Auteurs : | Geetanjali Gera ; Brett W. Fling ; Fay B. Horak |
Type de document : | Article |
Dans : | Archives of Physical Medicine and Rehabilitation (Vol. 101, n° 2, 2020) |
Article en page(s) : | p. 258-264 |
Note générale : | https://doi.org/10.1016/j.apmr.2019.07.011 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Cervelet ; Équilibre postural ; Imagerie par tenseur de diffusion ; Neuroimagerie ; Réadaptation ; Sclérose en plaques |
Résumé : |
Objective
To assess how postural sway deficits during eyes open and closed relate to the integrity of cerebellar peduncles in individuals with multiple sclerosis (MS). Design Cross-sectional study. Setting Laboratory based setting. Participants Twenty-nine adults with MS (Expanded Disability Status Scale: 2-4) and 15 adults without MS were recruited (N=44). Inclusion criteria for all participants were ability to maintain balance independently by standing on toes for 3 seconds, and no known biomechanical conditions affecting balance. Interventions Not applicable. Main Outcome Measures Postural sway using body-worn, inertial sensors during quiet standing, integrity of cerebellar peduncles quantified using diffusion-tensor imaging and clinical assessment scales for ataxia and balance. Results Radial diffusivity of the inferior cerebellar peduncle was related to postural sway measures during both eyes open and closed. In contrast, radial diffusivity of the superior cerebellar peduncle was related to postural sway only in stance with eyes open. Conclusions The inferior cerebellar peduncle, which carries somatosensory information to the cerebellum, contributes to control of standing balance with or without visual inputs, consistent with the high dependence on somatosensory information for posture. The superior cerebellar peduncle, which carries cortical information to the cerebellum, contributes to control of standing posture only when vision is available. Radial diffusivity of the inferior cerebellar peduncle was related to reactive balance control, whereas radial diffusivity of the superior cerebellar peduncle was related to the kinetic component of the ataxia rating scale. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S0003999319310020 |