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Titre : | Effect of vitamin D supplementation on serum lipid profiles: a systematic review and meta-analysis (2019) |
Auteurs : | Daniel T. Dibaba |
Type de document : | Article |
Dans : | Nutrition reviews (Vol. 77, n° 12, Décembre 2019) |
Article en page(s) : | p. 890-902 |
Note générale : | https://doi.org/10.1093/nutrit/nuz037 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Cholestérol ; Compléments alimentaires ; Lipides ; Lipoproteines ; Sang ; Vitamine D |
Mots-clés: | High-density lipoprotein (HDL) ; Low-density lipoprotein (LDL) |
Résumé : |
Context: Vitamin D deficiency is highly prevalent across the world. The existing evidence suggests vitamin D may have beneficial effects on serum lipid profiles and thus cardiovascular health.
Objective: The objective of this systematic review and meta-analysis was to examine the effect of vitamin D supplementation on serum lipid profiles. Data Source: Original randomized controlled trials (RCTs) examining the effect of vitamin D supplementation on serum lipid profiles and published before July 2018 were identified by searching online databases, including PubMed, Google Scholar, and ScienceDirect, using a combination of relevant keywords. Data Extraction: Data on study characteristics, effect size, measure of variation, type of vitamin D supplementation, and duration of follow-up were extracted by the author. Data Analysis: PRISMA guidelines for systematic reviews were followed. Random effects (DerSimonian and Laird [D-V)] models were used to pool standardized mean differences in total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides between the active and the placebo arms of RCT studies. Between-study heterogeneities were assessed using Cochrane Q and I2, and publication bias was assessed using Beggs test, Eggers test, and funnel plot. Results: A total of 41 RCTs comprising 3434 participants (n = 1699 in the vitamin D supplementation arm and n = 1735 in the placebo arm) were identified and included in the meta-analysis. Approximately 63.4% of study participants were women, with 14 studies conducted entirely among women. Approximately 24% of the trials had follow-up duration >6 months, whereas the remaining 76% had follow-up duration of Conclusions: Vitamin D supplementation appeared to have a beneficial effect on reducing serum total cholesterol, LDL cholesterol, and triglyceride levels but not HDL cholesterol levels. Vitamin D supplementation may be useful in hypercholesterolemia patients with vitamin D insufficiency who are at high risk of cardiovascular diseases. |
Disponible en ligne : | Oui/Non |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/77/12/890/5549277 |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
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Nutrition reviews. Vol. 77, n° 12 (Décembre 2019) | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |