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Titre : | Cognitive and behavioral neurology |
Type de document : | Périodique |
Langues: | Français |
Disponible en ligne : | Non |
Liste des numéros ou bulletins :
2011/4 (Déc. 2011)
Cognitive and behavioral neurology . 2011/4Paru le : 26/04/2013 |
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Titre : Beyond Alcoholism: Wernicke-Korsakoff Syndrome in Patients With Psychiatric Disorders (2013) Auteurs : Laurie McCormick ; et al. Type de document : Article Dans : Cognitive and behavioral neurology (2011/4, Déc. 2011) Article en page(s) : pp. 209-216 Langues: Français Descripteurs : HE Vinci
Malnutrition ; Schizophrénie ; ThiamineMots-clés: Encéphalopathie de Gayet-Wernicke ; Wernicke Encephalopathy ; Syndrome de Korsakoff ; Korsakoff Syndrome ; Schizophrenia Résumé : ObjectiveWernicke encephalopathy and Korsakoff syndrome (the combined disorder is named
Wernicke-Korsakoff syndrome [WKS]) are preventable, life-threatening neuropsychiatric
syndromes resulting from thiamine deficiency. WKS has historically been associated with
alcoholism; more recently, it has been recognized in patients who have anorexia nervosa or have
undergone bariatric surgery for obesity. However, patients with nutritional deficiencies of any
origin are at risk for WKS. We present clinical histories and neuroimaging data on 2 young adults
with underlying psychiatric disorders who became malnourished and developed WKS.
MethodsA young woman with bipolar disorder and somatization disorder was hospitalized for
intractable vomiting. A young man with chronic paranoid schizophrenia developed delusions that
food and water were harmful, and was hospitalized after subsisting for 4 months on soda pop.
ResultsAcute, life-threatening Wernicke encephalopathy was confirmed in both patients by
brain magnetic resonance imaging showing classic thalamic injury. The patients were left with
persistent cognitive and physical disabilities that were consistent with Korsakoff syndrome.
ConclusionsFailure to suspect a vitamin deficiency led to permanent cognitive and physical
disabilities that may necessitate lifelong care for these patients. The neuropsychiatric
consequences could have been prevented by prompt recognition of their thiamine deficiency.Disponible en ligne : Oui En ligne : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551444/pdf/nihms429357.pdf