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Titre : | Body Temperature Is Elevated and Linked to Fatigue in Relapsing-Remitting Multiple Sclerosis, Even Without Heat Exposure (2014) |
Auteurs : | James F. Sumowski ; Victoria M. Leavitt |
Type de document : | Article |
Dans : | Archives of Physical Medicine and Rehabilitation (2014/7, 2014) |
Article en page(s) : | p. 1298-1302 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Acide acétylsalicylique ; Fatigue ; Inflammation ; Rééducation et réadaptation ; Sclérose en plaques ; Température du corps |
Mots-clés: | Aspirin ; Body temperature ; Multiple sclerosis ; Multiple Sclerosis ; Relapsing-Remitting ; Sclérose en plaques récurrente-rémittente |
Résumé : |
Objectives To investigate whether (1) resting body temperature is elevated in patients with relapsing-remitting multiple sclerosis (RRMS) relative to healthy individuals and patients with secondary progressive multiple sclerosis (SPMS), and (2) warmer body temperature is linked to worse fatigue in patients with RRMS. Design Cross-sectional study. Setting Climate-controlled laboratory (∼22°C) within a nonprofit medical rehabilitation research center. Participants Patients with RRMS (n=50), matched healthy controls (n=40), and patients with SPMS (n=22). Intervention Not applicable. Main Outcome Measures Body temperature was measured with an aural infrared thermometer (normative body temperature for this thermometer, 36.75°C), and differences were compared across patients with RRMS and SPMS and healthy persons. Patients with RRMS completed measures of general fatigue (Fatigue Severity Scale [FSS]), as well as physical and cognitive fatigue (Modified Fatigue Impact Scale [MFIS]). Results There was a large effect of group (P<.001 whereby body temperature was higher in patients with rrms relative to healthy controls p=".009)" and spms warmer associated worse general fatigue rp=".315," physical subscale of the mfis but not cognitive mifs> Conclusions These are the first-ever demonstrations that body temperature is elevated endogenously in patients with RRMS and linked to worse fatigue. We discuss these findings in the context of failed treatments for fatigue in RRMS, including several failed randomized controlled trials (RCTs) of stimulants (modafinil). In contrast, our findings may help explain how RCTs of cooling garments and antipyretics (aspirin) have effectively reduced MS fatigue, and encourage further research on cooling/antipyretic treatments of fatigue in RRMS. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S0003999314001269 |