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Titre : | Rehabilitation Program After Mesenchymal Stromal Cell Transplantation Augmented by Vascularized Bone Grafts for Idiopathic Osteonecrosis of the Femoral Head: A Preliminary Study (2015) |
Auteurs : | Tomoki Aoyama ; yasuko Fujita ; Katsuyuki Madoba |
Type de document : | Article |
Dans : | Archives of Physical Medicine and Rehabilitation (2015/3, 2015) |
Article en page(s) : | p. 532-539 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Cellules stromales mésenchymateuses ; Ostéonécrose ; Rééducation et réadaptation |
Mots-clés: | Mesenchymal stromal cells ; Osteonecrosis |
Résumé : |
Objective To determine the feasibility and safety of implementing a 12-week rehabilitation program after mesenchymal stromal cell (MSC) transplantation augmented by vascularized bone grafting for idiopathic osteonecrosis (ION) of the femoral head. Design A prospective case series. Setting University clinical research laboratory. Participants Participants (N=10) with ION who received MSC transplantation augmented by vascularized bone grafting. Intervention A 12-week exercise program, which included range-of-motion (ROM) exercises, muscle-strengthening exercises, and aerobic training. Main Outcome Measures Measures of ROM, muscle strength, Timed Up and Go test, and Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) were collected before surgery and again at 6 and 12 months after surgery. Results All participants completed the 12-week program. External rotation ROM as well as extensor and abductor muscle strength significantly improved 6 months after treatment compared with that before treatment (P<.05 significant improvements were also seen in physical function role and bodily pain subgroup scores of the sf-36 no serious adverse events occurred.> Conclusions This study demonstrates the feasibility and safety of a multiplex rehabilitation program after MSC transplantation and provides support for further study on the benefits of rehabilitation programs in regenerative medicine. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S0003999314012106 |