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Titre : | Safety of Primed Repetitive Transcranial Magnetic Stimulation and Modified Constraint-Induced Movement Therapy in a Randomized Controlled Trial in Pediatric Hemiparesis (2015) |
Auteurs : | Bernadette T. Gillick ; Linda E. Krach ; Tim Feyma |
Type de document : | Article |
Dans : | Archives of Physical Medicine and Rehabilitation (2015/4 suppl., 2015) |
Article en page(s) : | p. S104-S113 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Accident vasculaire cérébral (AVC) ; Pédiatrie ; Rééducation et réadaptation ; Sécurité ; Stimulation magnétique transcranienne |
Mots-clés: | Pediatrics ; Safety ; Stroke ; Transcranial magnetic stimulation |
Résumé : |
Objective To investigate the safety of combining a 6-Hz primed low-frequency repetitive transcranial magnetic stimulation (rTMS) intervention in the contralesional hemisphere with a modified constraint-induced movement therapy (mCIMT) program in children with congenital hemiparesis. Design Phase 1 randomized, double-blinded, placebo-controlled pretest/posttest trial. Setting University academic facility and pediatric specialty hospital. Participants Subjects (N=19; age range, 817y) with congenital hemiparesis caused by ischemic stroke or periventricular leukomalacia. No subject withdrew because of adverse events. All subjects included completed the study. Interventions Subjects were randomized to 1 of 2 groups: either real rTMS plus mCIMT (n=10) or sham rTMS plus mCIMT (n=9). Main Outcome Measures Adverse events, physician assessment, ipsilateral hand function, stereognosis, cognitive function, subject report of symptoms assessment, and subject questionnaire. Results No major adverse events occurred. Minor adverse events were found in both groups. The most common events were headaches (real: 50%, sham: 89%; P=.14) and cast irritation (real: 30%, sham: 44%; P=.65). No differences between groups in secondary cognitive and unaffected hand motor measures were found. Conclusions Primed rTMS can be used safely with mCIMT in congenital hemiparesis. We provide new information on the use of rTMS in combination with mCIMT in children. These findings could be useful in research and future clinical applications in advancing function in congenital hemiparesis. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S0003999314011186 |