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Titre : | Elevated Circulating Levels of the Pro-Inflammatory Cytokine Macrophage Migration Inhibitory Factor in Individuals With Acute Spinal Cord Injury (2015) |
Auteurs : | Matthew Bank ; Adam Stein ; Cristina Sison |
Type de document : | Article |
Dans : | Archives of Physical Medicine and Rehabilitation (2015/4, 2015) |
Article en page(s) : | p. 633-644 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Inflammation ; Rééducation et réadaptation ; Traumatismes de la moelle épinière |
Mots-clés: | Cytokines ; Macrophage migration-inhibitory factors ; Facteurs inhibiteurs de la migration des macrophages ; Spinal cord injuries |
Résumé : |
Objective To test the hypothesis that macrophage migration inhibitory factor (MIF) is elevated in the circulation of individuals with acute spinal cord injury (SCI) compared with uninjured individuals. Design Prospective, observational pilot study. Setting Academic medical center. Participants Adults with acute traumatic SCI (n=18) and uninjured participants (n=18), comparable in age and sex distribution. Interventions Not applicable. Main Outcome Measures The primary outcome measure was the plasma MIF levels. Potential correlations were examined between MIF and clinical/demographic variables. The secondary outcome was to determine if other immune mediators were elevated in participants with acute SCI and if their levels correlated with the MIF. Results MIF was significantly elevated in subjects with acute SCI compared with control subjects at 0 to 3 (P<.0029 to and days postinjury at dpi levels of cytokines interleukin-6 interleukin-9 interleukin-16 interleukin-18 chemokines growth-related oncogene motif ligand macrophage inflammatory protein growth factors hepatocyte factor stem cell factor- were also significantly elevated in subjects with acute sci. the exception all these remained a subset hgf throughout study. within individuals mif correlated> Conclusions These data demonstrate that MIF is significantly elevated in subjects with acute SCI, supporting further investigation of MIF and other inflammatory mediators in acute SCI, where they may contribute to primary and secondary functional outcomes. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S0003999314012234 |