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Titre : | Neuroplasticity: An Appreciation From Synapse to System (2012) |
Auteurs : | Bernadette Gillick ; Lance Zirpel |
Type de document : | Article |
Dans : | Archives of Physical Medicine and Rehabilitation (2012/10, 2012) |
Article en page(s) : | pp. 1846-1855 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Imagerie par résonance magnétique ; Rééducation et réadaptation ; Stimulation magnétique transcranienne |
Mots-clés: | Gamma-aminobutyric acid ; Magnetic resonance imaging ; Motor cortex ; N-methylaspartate ; Receptors ; glutamate ; Transcranial magnetic stimulation ; Transcription ; genetic ; Acide gamma-amino-butyrique ; Cortex moteur ; N-Méthyl-aspartate ; Récepteurs au glutamate ; Transcription génétique |
Résumé : |
Gillick BT, Zirpel L. Neuroplasticity: an appreciation from synapse to system. Objective To integrate our functional knowledge in neurorehabilitation with a greater understanding of commonly held theories and current research in neuroplasticity. Design Literature review. Setting Not applicable. Participants Animal and human research. Interventions Interventions specific to application in humans: constraint-induced movement therapy, transcranial magnetic stimulation, and transcranial direct current stimulation. Main Outcome Measures Cortical excitability, blood oxygen leveldependent signal, and functional outcomes. Results There is increasing evidence elucidating the cellular and molecular mechanisms of plasticity of the nervous system including growth, modification, degradation, and even death of neurons. Some of these mechanisms directly correlate with therapy-induced behavioral changes, and all provide an understanding of the response of the nervous system to altered inputs. The understanding of neural correlates of behavior can then form the foundation for more productive, comprehensive interventions. Conclusions The focus of recent research surrounds translational projects aimed at enhancing clinical outcomes. Knowledge of mechanisms underlying this adaptability is the foundation for our treatments, diagnoses, and prognoses. The increasing understanding of the mechanisms underlying neuroplasticity can guide, direct, and focus the practice of current and future therapies to greater efficacy and better functional outcomes in clinical rehabilitation. |
Disponible en ligne : | Oui |
En ligne : | http://www.archives-pmr.org/article/S0003-9993%2812%2900343-7/abstract |