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Titre : | Calpain 1 in bronchoalveolar lavage fluid is associated with poor prognosis in lepidic predominant pulmonary adenocarcinoma (2019) |
Auteurs : | Anne-Marie Ruppert ; Laurent Baud ; Nathalie Rabbe ; Joëlle Perez ; Michaël Duruisseaux ; Thibault Vieira ; Martine Antoine ; Jacques Cadranel ; Marie Wislez |
Type de document : | Article |
Dans : | Bulletin du cancer (Vol. 106, n° 3, Mars 2019) |
Article en page(s) : | p. 179-188 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Adénocarcinome ; Granulocytes neutrophiles ; Récepteur de type Toll-2 ; Tumeurs du poumon |
Résumé : | Calpain 1 is a proinflammatory calcium-activated cysteine protease, which can be partly externalized. Extracellular calpains limit inflammatory processes and promote tissue repair, through cell proliferation and migration. Toll like receptor (TLR) 2 has been identified as a target of extracellular calpains in lymphocytes. The aim was to investigate the externalization of calpain 1 and the release of soluble TLR2 during tumor progression of pulmonary lepidic predominant adenocarcinoma (LPA). Extracellular calpain 1, soluble fragment of TLR2 and cytokines were analyzed by ELISA in bronchoalveolar lavage fluid (BALF) supernatants from patients with LPA (n=68). Source of calpain was analyzed by immunohistochemistry and soluble TLR2 by flow cytometry on polymorphonuclear neutrophils (PMN) and human lung cancer cell lines. Extracellular calpain 1, secreted by tumor cells, was associated to tumor progression, neutrophilic inflammation, with a poor prognostic factor on survival (P=0.003). TLR2 was expressed on PMN and tumor cells and decreased after calpain exposure. Soluble fragment of TLR2 in BALF supernatants was correlated to the extracellular calpain 1 concentration (r=0.624; P |
Disponible en ligne : | Non |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
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REV | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |