| Titre : | Identification of risk factors of central lymph node metastasis and evaluation of the effect of prophylactic central neck dissection on migration of staging and risk stratification in patients with clinically node-negative papillary thyroid microcarcinoma (2017) |
| Titre original: | Identification des facteurs de risque d’atteinte ganglionnaire centrale et évaluation de l’effet du curage cervical central sur le stade et la stratification du risque chez les patients atteints de microcarcinome papillaire thyroïdien sans adénopathie clinique |
| Auteurs : | Yuan Jiru ; Jinghua Li ; Xiaoyi Chen ; et al. |
| Type de document : | Article |
| Dans : | Bulletin du cancer (Vol. 104, n° 6, Juin 2017) |
| Article en page(s) : | p. 516-523 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Carcinomes ; Facteurs de risque ; Métastase ; Tumeurs de la thyroïde |
| Résumé : |
Objective
The first aim of this study was to explore the risk factors that were associated with central lymph node metastasis (CLNM) in patients with clinically node-negative papillary thyroid microcarcinoma (cN0 PTMC) after prophylactic central neck dissection (PCND). The second aim was to evaluate the influence of PCND on migration of TNM staging and risk stratification (RS) in patients with cN0 PTMC. Methods A total of 295 cN0 PTMC patients who underwent thyroidectomy with PCND in the Department of General Surgery at Guangdong General Hospital between March 2014 to December 2015 were assessed retrospectively. The relations of CLNM with clinicopathologic characteristics of cN0 PTMC were analyzed by univariate and multivariate logistic regression. The effect of PCND on migration of TNM staging and RS was also observed. Results The incidence of CLNM was 42.4% (125 of 295 cases) in patients with cN0 PTMC. Univariate analysis showed that age (P=0.000), ultrasonographic tumor size (P=0.009), pathologic tumor size (P=0.005), and multifocality (P=0.031) were significantly associated with the incidence of CLNM. No significant correlations were found between the presence of CLNM and other variables such as gender (P=0.399), bilaterality (P=0.118), capsular invasion (P=0.111), lymphovascular invasion (P=0.184), extent of thyroidectomy (P=0.319) and lymphadenectomy (P=0.458). Multivariate logistic regression analysis revealed that age Conclusions CLNM is highly prevalent in cN0 PTMC. Age |
| Disponible en ligne : | Non |
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