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Titre : | Colorectal cancer: Can nutrients modulate NF-?B and apoptosis? (2010) |
Auteurs : | P. Ravasco ; M. Aranha ; P. Borralho ; Collectif |
Type de document : | Article |
Dans : | Clinical nutrition (vol 29 n° 1, 2010) |
Article en page(s) : | pp. 42-46 |
Descripteurs : |
HE Vinci Tumeurs du côlon |
Résumé : | Summary Background & aims NF-?B may promote carcinogenesis by altering cell cycle, inflammatory responses and apoptosis-related gene expression, though cell mechanisms relating diet and colorectal cancer (CRC) remain unveiled in humans. This study in patients with CRC aimed to explore potential interactions between the dietary pattern, nutrient intake, expression of NF-?B, apoptosis and tumour histological aggressiveness. Methods Usual diet was assessed by diet history; nutrient composition was determined by DIETPLAN software. Histologically classified patient tissue samples (adenoma, adenocarcinoma and normal surrounding mucosa) were obtained via biopsies during colonoscopy (n = 16) or surgery (n = 8). NF-?B expression was determined by immunohistochemistry and apoptosis by TUNEL assay. Results NF-?B expression and apoptosis were higher in tumours (p |
Disponible en ligne : | Non |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
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REV | Périodique papier | Woluwe | Espace revues | Prêt autorisé Disponible |