| Titre : | Concepts in Biochemistry |
| Auteurs : | R. Boyer |
| Type de document : | Livre |
| Mention d'édition : | 3rd ed. |
| Editeur : | New York : Wiley, 2006 |
| Format : | 720p |
| Index. décimale : | 577 (Biochimie) |
| Descripteurs : |
HE Vinci Analyse de concept ; Biochimie |
| Résumé : | The third edition of Concepts in Biochemistry makes the most applied and accessible biochemistry text on the market. Students are more successful with Boyer because it isn't intimidating and it makes clear the relevance of the material to their future careers. Like the first two editions, Boyer is written for students who need an introduction to the fundamental principles of biochemistry and are preparing for a career in the allied health sciences, the biological sciences, and the environmental sciences. (The text is also appropriate for use in one-semester courses developed for chemistry majors as a result of the new American Chemical Society requirements for three-credit hours of biochemistry coursework.) The modern, student-friendly organization sets the book apart from the competition because the early placement of nucleic acids enhances the traditional coverage of protein structure and function, and metabolism. As an example, it is now possible to present metabolism in a more contemporary fashion, emphasizing gene regulation and integration. Sommaire Part 1:Molecules and Life 1 Biochemistry: From Atoms to Molecules to Cells. 1.1 The Roots of Biochemistry. Early History of Biochemistry. The Road to Modern Biochemistry. 1.2 All Living Matter Contains C, H, O, N, P, and S. Chemical Elements in Biomolecules. Combining Elements into Compounds. Just in Time Review Important Functional Groups in Biochemistry. 1.3 Biological Macromolecules. Cellular Reactions. 1.4 Organelles, Cells, and Organisms. Viruses. Living Cells. Prokaryotic Cells. Window on Biochemistry 1-1 ExtremophilesLiving Life on the Edge. Eukaryotic Cells. 1.5 Storage and Transfer of Biological InformationA Preview. Biological Information. Just in Time Review Biochemistry Comes in All Sizes S, M, L, and XL. The DNA Molecule. DNA DNA. DNA RNA. mRNA Proteins. The Genetic Code. Eukaryotic DNA: Exons and Introns. DNA Mutations. Window on Biochemistry 1-2 Capturing and Handling Cell Components. Biochemistry in the Clinic 1-1 Obesity. Summary 33 / Study Exercises 33 / Further Reading. 2 Biomolecules in Water. 2.1 Water, the Biological Solvent. Noncovalent Interactions in Biomolecules. Examples of Noncovalent Interactions. Characteristics of Noncovalent Interactions. The Structure of Water. The Importance of Hydrogen Bonds. 2.2 Hydrogen Bonding and Solubility. Physical Properties of Water. Water as a Solvent. 2.3 Cellular Reactions of Water. Ionization of Water. Just in Time Review Using pH to Define Hydrogen Ion Concentration. pH and pK. Titration Curves. The Henderson-Hasselbalch Equation. Drug Efficacy Depends on Water Solubility. 2.4 Buffer Systems. Maintaining a Constant pH. Effective Buffering Range. Laboratory Buffers. Window on Biochemistry 2-1 Buffers in Blood and Other Cellular Fluids. Biochemistry in the Clinic 2-1 Aspirin Overdose and Salicylate Poisoning. Summary 59 / Study Exercises 59 / Further Reading. 3 Amino Acids, Peptides, and Proteins. 3.1 The Amino Acids in Proteins. Properties of _-Amino Acids. Classification of Amino Acids. Window on Biochemistry 3-1 Identifying the 21st and 22nd Standard Amino Acids. Reactivity and Analysis of Amino Acids. 3.2 Polypeptides and Proteins. Window on Biochemistry 3-2 Bacteria Use Amino Acids to Gather a Crowd. 3.3 Protein Function. Enzymes. Structural Proteins. Immune Proteins. Transport and Storage Proteins. Regulatory and Receptor Proteins. Muscle Contraction and Mobility Proteins. 3.4 Structural Properties of Proteins. Molecular Mass. Defining Protein Composition and Behavior. Four Levels of Protein Structure. 3.5 Studying Protein Structure and Function. Proteomics. Isolating and Purifying Proteins. Determination of Primary Structure. Sequencing DNA. Importance of Protein Sequence Data. Biochemistry in the Clinic 3-1 Monosodium GlutamateThe Taste of Umami. Summary 91 / Study Exercises 92 / Further Reading. 4 Protein Architecture and Biological Function. 4.1 General Principles of Protein Design. Influence of Primary Sequence. Noncovalent Interactions. Structure of Peptide Bonds. 4.2 Elements of Secondary Structure. The _-Helix. _-Sheets. Bends and Loops. Supersecondary Structure. Fibrous Proteins. 4.3 Protein Tertiary Structure. Elements of Tertiary Structure. The Protein Folding Process. Folding Accessory Proteins. Protein Unfolding. Window on Biochemistry 4-1 Misadventures in Protein Folding and Disease. 4.4 Protein Quaternary Structure. Monomeric and Oligomeric Proteins. 4.5 Protein Structure and Biological Function. Hemoglobin. Window on Biochemistry 4-2 How Do Hemoglobin and Myoglobin Tell the Difference Between O2 and CO? _-Keratin. Bacterial and Bovine Rhodopsin. Biochemistry in the Clinic 4-1 Prionsthe Rogue Proteins. Summary /Study Exercises /Further Reading. Part 2:Dynamic Function of Biomolecules 5 Enzymes I: Reactions, Kinetics, and Inhibition. 5.1 Enzymes as Biological Catalysts. Introduction to Enzymes. Catalytic Properties of Enzymes. Enzymes and Cofactors. Window on Biochemistry 5-1 A Heat-Stable Enzyme Catalyzes Green Chemistry. Naming of Enzymes. 5.2 The Kinetic Properties of Enzymes. Michaelis-Menten Equation. Just in Time Review KineticsThe Study of Reaction Rates. Kinetic Constants KM, Vmax, and k3. Window on Biochemistry 5-2 The Lineweaver-Burke PlotStraightening Out Enzyme Kinetics. Characteristics of Enzyme Reactions. 5.3 Substrate Binding and Enzyme Action. Enzyme Active Sites. General Acid-Base Catalysis. Metal-Ion Catalysis. Covalent Catalysis. 5.4 Enzyme Inhibition. Reversible and Irreversible Inhibition. Competitive Inhibition. Noncompetitive Inhibition. Uncompetitive Inhibition. Enzyme Inhibition in the Lab. Window on Biochemistry 5-3 CurcuminA Curry Ingredient That Slows Tumor Growth by Enzyme Inhibition. Biochemistry in the Clinic 5-1 Protease InhibitorsA Tale of Two Diseases. Summary / Study Exercises/ Further Reading. 6 Enzymes II: Coenzymes, Regulation, Abzymes, and Ribozymes. 6.1 Enzyme: Coenzyme Partners. Coenzymes. Vitamins. Metals as Nutrients. 6.2 Allosteric Enzymes. Window on Biochemistry 6-1 The Newest Vital AmineCholine. Positive and Negative Effectors. Models to Describe Allosteric Regulation. 6.3 Cellular Regulation of Enzymes. Covalent Modification of Regulatory Enzymes. Activation by Proteolytic Cleavage. Regulation by Isoenzymes. 6.4 Design of New Enzymes. Site-Directed Mutagenesis. Abzymes. Window on Biochemistry 6-2 Those Promiscuous Enzymes. 6.5 Ribozymes. Ribonuclease P. Self-splicing RNA Introns. Significance of Ribozymes. Window on Biochemistry 6-3 The Smallest Ribozyme? 6.6 Biological Catalysts in the Future. Enzyme Structure and Action. Enzyme Action in the Cell. Ribozymes. Practical Uses of Enzymes. Biochemistry in the Clinic 6-1 A Viral Enzyme That Kills Bacillus anthracis. Summary/ Study Exercises/ Further Reading. 7 Carbohydrates: Structure and Biological Function. 7.1 Monosaccharides. Aldoses. Ketoses. 7.2 Carbohydrates in Cyclic Structures. Hemiacetals and Hemiketals. Anomers and Haworth |
| Disponible en ligne : | Non |
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| Cote | Support | Localisation | Section | Disponibilité |
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| 577 BOY | Livre | Woluwe | Espace livres | Prêt autorisé Disponible |
