Login
Communauté Vinci
Extérieur
Si votre nom d'utilisateur ne se termine pas par @vinci.be ou @student.vinci.be, utilisez le formulaire ci-dessous pour accéder à votre compte de lecteur.
Titre : | The use of dried blood spots in antidoping: advantages and limitations (2024) |
Auteurs : | Olivier Salamin ; Martial Saugy |
Type de document : | Article |
Dans : | actualité chimique (L') (492, février 2024) |
Article en page(s) : | p.29-34 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Dopage sportif ; Echantillon ; Sang |
Mots-clés: | Dépistage sur goutte de sang séché ; Gouttelette de sang séché (DBS) ; microéchantillonnage ; sang capillaire ; détection directe |
Résumé : | The adoption of dried blood spots (DBS) in antidoping has marked a transformative shift in the landscape of sample collection and analysis. This review explores the compelling advantages and inherent limitations associated with the use of DBS in antidoping efforts. One of the most notable advantages of DBS lies in its streamlined sample collection, transportation, and storage processes. The simplicity of DBS sample collection minimizes invasiveness, rendering it athlete-friendly and promoting more frequent testing. Furthermore, DBS samples are exceptionally stable, preserving the integrity of analytes within the dried matrix. This stability allows for prolonged sample storage without significant degradation, offering flexibility and cost-efficiency in sample management. In addition to these advantages, DBS simplifies the analytical process, facilitating large-scale screenings for prohibited substances. The methods practicality and efficiency make it a valuable tool for antidoping organizations seeking to conduct widespread analyses. Moreover, the information obtained from DBS can complement the interpretation of urine samples, enhancing result management. In cases of suspicious or non-conclusive findings, DBS data can serve as valuable supplementary evidence, aiding antidoping authorities in making informed decisions. However, DBS is not without its challenges. The hematocrit effect, a critical consideration, can lead to variations in analyte quantification due to fluctuations in individual hematocrit levels. This poses a significant hurdle in maintaining consistent sensitivity and accuracy. The limited volume of blood collected in DBS samples can also restrict sensitivity, particularly when detecting substances present in minute concentrations. Furthermore, the current regulatory framework confines the use of DBS to the detection of substances without predefined thresholds or minimum reporting levels, limiting its applicability to specific doping agents. It is important to recognize that the implementation of DBS in antidoping is still in its nascent stage. While initial experiences with DBS have shown promise, the true impact of this innovative approach on antidoping efforts will become increasingly apparent over the next two to three years. Importantly, DBS is not intended to replace conventional urine or blood collection methods but rather to complement them. This integration promises to enhance the comprehensiveness of antidoping practices and improve the fairness and integrity of sports antidoping measures. |
Disponible en ligne : | Non |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
---|---|---|---|---|
actualité chimique (L'). 492 (février 2024) | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |